發(fā)布時(shí)間：2018-07-24 08:01

【摘要】：目的:觀察烏司他丁(UTI)對急性呼吸窘迫綜合征(ARDS)患者療效、炎癥因子及細(xì)胞免疫狀態(tài)的影響。方法:將96例ARDS患者隨機(jī)分為兩組:對照組(48例)給予常規(guī)治療;UTI組(48例)在對照組治療的基礎(chǔ)上應(yīng)用UTI。比較兩組患者治療前后氧合指數(shù)、生命體征、炎癥因子及T淋巴細(xì)胞亞群的變化,并記錄兩組患者的機(jī)械通氣時(shí)間、ICU治療時(shí)間及ICU內(nèi)死亡率。結(jié)果:治療7 d后,UTI組患者的生命體征(RF、HR、MAP)、炎癥因子(TNF-a、IL-6、IL-8、PCT、CRP、WBC)、肝功能(AST、ALT)、腎功能(BUN、Cr)及APACHEⅡ評分、MODS評分均低于對照組(P0.05或P0.01),氧合指數(shù)(PaO_2/FiO_2)及細(xì)胞免疫(CD4~+、CD4~+/CD8~+)均高于對照組(P0.01)。UTI組患者的機(jī)械通氣時(shí)間、ICU治療時(shí)間短于對照組(均P0.05),UTI組患者的ICU內(nèi)死亡率低于對照組(P0.05)。兩組患者不良反應(yīng)發(fā)生率差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:UTI用于ARDS能更有效地改善氧代謝和生命體征,改善肝腎功能,降低APACHEⅡ評分、MODS評分,縮短機(jī)械通氣時(shí)間、ICU治療時(shí)間,降低ICU內(nèi)死亡率,其機(jī)制可能與UTI清除體內(nèi)炎癥因子和調(diào)節(jié)細(xì)胞免疫功能有關(guān)。
[Abstract]:Aim: to observe the effects of ulinastatin (UTI) on the efficacy, inflammatory factors and cellular immunity of patients with acute respiratory distress syndrome (ARDS). Methods: 96 patients with ARDS were randomly divided into two groups: the control group (n = 48) received routine treatment and the control group (n = 48) were treated with UTI on the basis of the control group. The changes of oxygenation index, vital signs, inflammatory factors and T lymphocyte subsets were compared between the two groups before and after treatment, and the time of mechanical ventilation and the mortality in ICU were recorded. Results: after 7 days of treatment, the vital signs (RFHRMAP), inflammatory factors (TNF-aIL-6 / IL-8), liver function (ASTnalt), renal function (Buchr) and APACHE 鈪，

本文編號：2140740