A~2DS~2評分聯(lián)合血糖對急性缺血性卒中相關性肺炎發(fā)生的預測價值研究
發(fā)布時間:2018-07-17 06:15
【摘要】:目的:探索A~2DS~2評分聯(lián)合血糖后是否可以提高對急性缺血性腦卒中患者卒中相關性肺炎(SAP)發(fā)生風險的預測價值。方法:回顧性連續(xù)收集2012年1月至2016年12月山西醫(yī)科大學第一醫(yī)院神經(jīng)內(nèi)科收治的在發(fā)病7天內(nèi)入院的急性缺血性腦卒中患者的病例資料,包括年齡、性別、房顫、吞咽困難、NIHSS評分、入院血糖、空腹血糖和梗死部位,并計算A~2DS~2評分。對所有納入對象采用改良CDC標準或Mann’s標準診斷SAP。多元Logistic回歸分析計算入院高血糖(≥11.1mmol/L)、空腹高血糖(≥7.1mmol/L)、入院或空腹高血糖的調(diào)整OR值并確定血糖預測SAP發(fā)生風險的分值,與A~2DS~2評分聯(lián)合生成新的評分量表。用ROC曲線分析分別繪制A~2DS~2評分和新評分量表的ROC曲線圖,并計算A~2DS~2評分和m A~2DS~2評分的曲線下面積(AUC),AUC0.5表示有預測價值,比較A~2DS~2評分和m A~2DS~2評分的AUC,AUC越大,預測價值越高。P0.05認為差異有統(tǒng)計學意義。并計算各自的最佳截斷值的靈敏度和特異度。結(jié)果:共納入符合標準的急性缺血性腦卒中患者2552例,平均年齡61.85(±12.70)歲,肺炎發(fā)病率7.8%。入院高血糖、空腹高血糖、入院/空腹高血糖對SAP的調(diào)整OR值分別是1.04(P=0.885)、2.86(P0.05)、1.14(P=0.475)?崭垢哐鞘荢AP的獨立危險因素,其調(diào)整OR值在2-4之間,賦值2分,與A~2DS~2評分聯(lián)合后生成改良A~2DS~2評分(mA~2DS~2評分)。A~2DS~2評分和mA~2DS~2評分的分值越高,SAP的發(fā)病率也越高。A~2DS~2評分和mA~2DS~2評分的AUC(95%CI)分別是0.793(0.777,0.809)和0.814(0.798,0.828),且mA~2DS~2評分的AUC大于A~2DS~2評分(Z=2.704,P0.05),差異有統(tǒng)計學意義。在本研究中,A~2DS~2評分的最佳截斷值是3分,靈敏度81.5%,特異度62.2%,mA~2DS~2評分的最佳截斷值是4分,靈敏度83.5%,特異度64.9%。結(jié)論:1.空腹高血糖是SAP的獨立危險因素;2.在本研究中,A~2DS~2評分和mA~2DS~2評分都是簡便有效的急性缺血性腦卒中患者SAP發(fā)生風險的預測評分量表;3.在本研究中,mA~2DS~2評分對SAP發(fā)生風險的預測價值優(yōu)于A~2DS~2評分。
[Abstract]:Objective: to explore whether the combination of A2 DS2 score and blood glucose can improve the predictive value of acute ischemic stroke patients with stroke associated pneumonia (SAP). Methods: data of patients with acute ischemic stroke admitted within 7 days from January 2012 to December 2016 in the Department of Neurology, first Hospital of Shanxi Medical University, including age, sex, atrial fibrillation, were collected retrospectively. NIHSS, admission blood glucose, fasting blood glucose and infarct location were evaluated. All subjects were diagnosed with improved CDC criteria or Mannus criteria. Multivariate logistic regression analysis was used to calculate admission hyperglycemia (鈮,
本文編號:2129358
[Abstract]:Objective: to explore whether the combination of A2 DS2 score and blood glucose can improve the predictive value of acute ischemic stroke patients with stroke associated pneumonia (SAP). Methods: data of patients with acute ischemic stroke admitted within 7 days from January 2012 to December 2016 in the Department of Neurology, first Hospital of Shanxi Medical University, including age, sex, atrial fibrillation, were collected retrospectively. NIHSS, admission blood glucose, fasting blood glucose and infarct location were evaluated. All subjects were diagnosed with improved CDC criteria or Mannus criteria. Multivariate logistic regression analysis was used to calculate admission hyperglycemia (鈮,
本文編號:2129358
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