本文選題：鹽酸水蘇堿 + 急性腦梗死�。� 參考：《中國病理生理雜志》2017年10期

【摘要】：目的:觀察鹽酸水蘇堿對實(shí)驗(yàn)性急性腦梗死大鼠的治療效果,并探討其可能作用機(jī)制。方法:將75只大鼠隨機(jī)分為5組:假手術(shù)組、腦梗死組及不同劑量鹽酸水蘇堿治療組,每組各15只。鹽酸水蘇堿治療組大鼠在造模完成后分別給予鹽酸水蘇堿10 mg/kg、20 mg/kg和40 mg/kg灌胃,每天1次,連續(xù)給藥14 d。給藥完成后,對各組大鼠進(jìn)行神經(jīng)功能缺損評分,計(jì)算腦梗塞體積,干濕重法檢測腦含水量,Western blot法檢測腦組織中β-catenin、cyclin D1、糖原合成酶激酶3β(GSK-3β)和p-GSK-3β的蛋白水平。結(jié)果:與腦梗死組相比,鹽酸水蘇堿治療后大鼠的神經(jīng)功能缺損評分明顯降低,腦梗死體積與腦含水量明顯降低,β-catenin、cyclin D1和p-GSK-3β的蛋白水平明顯升高。結(jié)論:鹽酸水蘇堿對實(shí)驗(yàn)性大鼠急性腦梗死具有一定的療效,其機(jī)制可能與激活了Wnt/β-catenin信號通路有關(guān)。
[Abstract]:Aim: to observe the therapeutic effect of stachydrine hydrochloride on experimental acute cerebral infarction rats and explore its possible mechanism. Methods: 75 rats were randomly divided into 5 groups: sham operation group, cerebral infarction group and stachydrine hydrochloride treatment group with 15 rats in each group. Rats in the stachydrine hydrochloride treatment group were treated with 10 mg / kg of stachydrine hydrochloride for 20 mg/kg and 40 mg/kg, respectively, once a day for 14 days. After administration, the neurological impairment scores were evaluated, the volume of cerebral infarction was calculated, the brain water content and the protein levels of 尾 -catenin cyclin D1, glycogen synthase kinase 3 尾 (GSK-3 尾) and p-GSK-3 尾 in brain tissue were measured by dry and wet weight method. Results: compared with the cerebral infarction group, the neurological impairment score, cerebral infarction volume and cerebral water content were significantly decreased, and the protein levels of 尾 -cateninine cyclin D1 and p-GSK-3 尾 were significantly increased in rats treated with stachydrine hydrochloride. Conclusion: stachydrine hydrochloride has a certain therapeutic effect on experimental acute cerebral infarction in rats, and its mechanism may be related to the activation of Wnt- 尾 -catenin signaling pathway.
【作者單位】： 新疆石河子大學(xué)醫(yī)學(xué)院第一附屬醫(yī)院神經(jīng)內(nèi)科;
【基金】：兵團(tuán)應(yīng)用基礎(chǔ)研究計(jì)劃(No.2015AG014)
【分類號】：R743.33
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本文編號：2064251