本文選題：創(chuàng)傷 + 消毒藥(劑)　； 參考：《中國(guó)全科醫(yī)學(xué)》2016年11期

【摘要】：目的了解臨床常用傷口抗菌敷料百格斯、乳酸依沙吖啶和碘伏對(duì)頭面部感染傷口的療效、成本以及細(xì)胞增殖毒性。方法回顧性分析2013年7月—2014年4月北京同仁醫(yī)院急診外科收治的各種原因所致頭面部皮膚裂傷清創(chuàng)縫合術(shù)后感染患者46例,根據(jù)采用的抗菌溶液不同,將患者分為百格斯組(16例)、碘伏組(15例)及乳酸依沙吖啶組(15例),分別采用相應(yīng)消毒劑進(jìn)行換藥。記錄患者傷口愈合時(shí)間及治療費(fèi)用。將CHL(中國(guó)倉(cāng)鼠成纖維肺細(xì)胞)接種于96孔板,分別稀釋碘伏(0.000 5%~0.1%)、過氧化氫(0.002 5%~0.5%)、百格斯(0.1%~20%)及乳酸依沙吖啶(0.5%~100%)至8個(gè)不同濃度,加入培養(yǎng)基孵育6 h。用酶標(biāo)儀在450 nm波長(zhǎng)處檢測(cè)各孔的吸光度(OD)值,以吸光率(%)=(OD_(待測(cè)組)/OD_(對(duì)照組))×100%評(píng)估細(xì)胞增殖抑制率。結(jié)果百格斯組、碘伏組和乳酸依沙吖啶組愈合時(shí)間、7 d愈合率及14 d愈合率比較,差異均無統(tǒng)計(jì)學(xué)意義(P0.05)。各組治療費(fèi)用比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05);其中,碘伏組和乳酸依沙吖啶組治療費(fèi)用低于百格斯組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。孵育6 h后,細(xì)胞增殖抑制率為乳酸依沙吖啶(41.922%)百格斯(5.528%)過氧化氫(0.058%)碘伏(0.006%)。結(jié)論與碘伏和乳酸依沙吖啶比較,應(yīng)用百格斯對(duì)頭面部感染傷口治愈時(shí)間和治愈率均未見顯著差異,但治療費(fèi)用較高,細(xì)胞增殖毒性中等。患者可根據(jù)免疫力及經(jīng)濟(jì)水平,選擇合理消毒劑。
[Abstract]:Objective to investigate the efficacy, cost and cytotoxicity of bactericidal dressing, ethacridine lactate and iodophor in the treatment of head and face infection wounds. Methods from July 2013 to April 2014, 46 patients with head and facial skin laceration after debridement and suture were retrospectively analyzed. The patients were divided into Biggs group (n = 16) and iodophor group (n = 15) and ethacridine lactate group (n = 15). The wound healing time and treatment cost were recorded. CHL (Chinese hamster fibroblast) was inoculated on 96 well plate and diluted with 0. 5% iophor 0.000 and 0. 1%, respectively. Hydrogen peroxide 0.002 5 5 was added to culture medium for 6 h. The concentration of CHL was 0. 0025. 0. 5 and 20%) and ethacridine lactic acid was 0. 5 and 0. 5%, respectively) and incubated in culture medium for 6 h. The absorbance and ODV values of each hole were detected at 450 nm wavelength by enzyme labeling instrument, and the inhibition rate of cell proliferation was evaluated by the absorptivity of ODSP (the group to be tested) / ODSP (control group) 脳 100%. Results there was no significant difference in the healing time of 7 days and 14 days in Baiggs group, iodophor group and ethacridine lactate group. The treatment cost of each group was significantly lower than that of Biggs group (P 0.05), and the treatment cost of iodophor group and lactic acid ethacridine group was lower than that of Biggs group (P 0.05). After incubation for 6 h, the inhibition rate of cell proliferation was 41.922% ethacridine lactic acid (41.922) and (5.528%) hydrogen peroxide (0.058). Conclusion compared with iodophor and ethacridine lactate, there is no significant difference in cure time and cure rate of head and face infection wound treated with Baigs, but the cost of treatment is higher and the toxicity of cell proliferation is moderate. The patient can choose reasonable disinfectant according to immunity and economic level.
【作者單位】： 首都醫(yī)科大學(xué)附屬北京同仁醫(yī)院急診科;中國(guó)食品藥品檢定研究院國(guó)家藥物安全評(píng)價(jià)監(jiān)測(cè)中心 藥物非臨床安全評(píng)價(jià)研究北京市重點(diǎn)實(shí)驗(yàn)室;
【分類號(hào)】：R641
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本文編號(hào)：2010292