本文選題：急性ST段抬高型心肌梗死 + 經(jīng)皮冠狀動脈介入治療　； 參考：《山西醫(yī)科大學》2017年碩士論文

【摘要】：目的:探討復方丹參滴丸對急性ST段抬高型心肌梗死(STEMI)患者直接經(jīng)皮冠狀動脈介入治療(PCI)療效的影響。方法:入選2015年1月-2016年10月山西大醫(yī)院因初發(fā)急性STEMI并行直接PCI患者160例,采納隨機數(shù)字表法隨機將其分為2組,試驗組76人,對照組84人。對照組給予常規(guī)治療,試驗組在常規(guī)治療基礎(chǔ)上PCI術(shù)前服用復方丹參滴丸10丸,術(shù)后每日3次,每次10粒。記錄PCI干預前、后IRA血流TIMI分級及校正的TIMI幀數(shù)(CTFC)、治療期間不良心血管事件(MACE)發(fā)生率、術(shù)后即刻和3月后左心室射血分數(shù)(LVEF)和室壁運動記分指數(shù)(WMSI)的差異。結(jié)果:兩組患者PCI干預前IRA血流TIMI分級無差異(P0.05),試驗組患者PCI干預后IRA血流TIMI分級優(yōu)于對照組(P0.05),試驗組CTFC小于對照組(P0.05);試驗組患者MACE發(fā)生率低于對照組(P0.05),但其中心源性休克發(fā)生率無統(tǒng)計學差異(P0.05);試驗組患者術(shù)后3月LVEF及WMSI均較術(shù)后即刻或?qū)φ战M有明顯改善(P0.05)。結(jié)論:急性心肌梗死患者在冠心病二級預防藥物治療的基礎(chǔ)上,PCI術(shù)前和術(shù)后服用復方丹參滴丸能更好地增加冠脈血流,減少MACE發(fā)生,提高左室射血分數(shù),提示復方丹參滴丸可以改善心肌灌注,抑制心室重塑,改善左室功能,有助于患者長期預后。
[Abstract]:Objective: to investigate the effect of compound Danshen dropping pills on patients with acute ST-segment elevation myocardial infarction (STEMI) treated with direct percutaneous coronary intervention (PCI). Methods: 160 patients with primary acute STEMI and direct PCI in Shanxi Great Hospital from January 2015 to October 2016 were randomly divided into two groups: experimental group (n = 76) and control group (n = 84). The control group was treated with routine therapy, the experimental group took 10 pills of compound Danshen drop pills before PCI, 10 pills per day three times a day after PCI. Before and after PCI intervention, the TIMI grading of IRA blood flow and the corrected TIMI frame count were recorded. The incidence of adverse cardiovascular events (MACEC), left ventricular ejection fraction (LVEF) and ventricular wall motion score index (WMSI) were compared immediately and 3 months after PCI. Results: there was no difference in TIMI grade of IRA blood flow between the two groups before PCI intervention. After PCI intervention, the TIMI grade of IRA blood flow in the trial group was better than that in the control group (P 0.05), the CTFC in the trial group was lower than that in the control group (P 0.05), the incidence of Mace in the trial group was lower than that in the control group (P 0.05), but the rate of Mace in the trial group was lower than that in the control group. There was no significant difference in the incidence of cardiogenic shock (P 0.05). LVEF and WMSI were significantly improved 3 months after operation in the trial group compared with those in the control group or immediately after operation. Conclusion: taking compound salvia miltiorrhiza drop pill before and after PCI can increase coronary blood flow, reduce Mace and increase left ventricular ejection fraction in patients with acute myocardial infarction. The results suggest that compound Danshen dropping pill can improve myocardial perfusion, inhibit ventricular remodeling, improve left ventricular function, and contribute to the long-term prognosis of patients.
【學位授予單位】：山西醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R542.22

【參考文獻】

相關(guān)期刊論文 前10條

1 陳偉偉;高潤霖;劉力生;朱曼璐;王文;王擁軍;吳兆蘇;李惠君;顧東風;楊躍進;鄭哲;蔣立新;胡盛壽;;《中國心血管病報告2015》概要[J];中國循環(huán)雜志;2016年06期

2 ;急性ST段抬高型心肌梗死診斷和治療指南[J];中華心血管病雜志;2015年05期

3 冷靜;傅超美;萬方;;三七三醇皂苷化學成分及藥理作用的研究進展[J];華西藥學雜志;2011年01期

4 賈智;;復方丹參片聯(lián)合維生素C片治療冠心病心絞痛療效觀察[J];現(xiàn)代醫(yī)藥衛(wèi)生;2010年22期

5 陳煥清;熊小強;段朝暉;韓智娟;張向葵;趙鳳如;;復方丹參滴丸對冠心病血管內(nèi)皮功能的干預及其機制[J];中山大學學報(醫(yī)學科學版);2009年S4期

6 劉培良;沈菀真;靖濤;周卓;陳瑤;李軒;袁龍;;復方丹參滴丸及阿司匹林對老年ACS患者血小板聚集功能及PKB活性變化的影響[J];中國新藥雜志;2009年10期

7 宋軍;;中西醫(yī)結(jié)合醫(yī)學在中醫(yī)藥創(chuàng)新發(fā)展中的作用[J];中國中西醫(yī)結(jié)合雜志;2009年04期

8 袁如玉;李廣平;;復方丹參滴丸在心血管疾病防治中的多靶點作用[J];中國新藥雜志;2009年05期

9 官波;牛秀明;;復方丹參滴丸作用機制研究進展[J];山東醫(yī)藥;2008年40期

10 趙世杰;田文;齊國先;李亞明;李雪娜;;急性心肌梗死急診介入治療后心肌組織水平再灌注評價方法對比研究[J];中國醫(yī)師進修雜志;2008年28期

，

本文編號：2001896