本文選題：急性腦梗死 + 血清　； 參考：《中南大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年03期

【摘要】：目的:觀察急性腦梗死患者血清泛素羧基末端水解酶-1(ubiquitin C-terminal hydrolase-L1,UCH-L1)和血清膠質(zhì)纖維酸性蛋白(serum glial fibrillary acidic protein,GFAP)的臨床表達(dá)水平,并探討二者對(duì)腦梗死患者的臨床意義。方法:選取重慶市腫瘤醫(yī)院在2014年1月至2016年2月期間收治的80例急性腦梗死患者作為觀察組,另選取同時(shí)段來院做體格檢查的80例健康者作為對(duì)照組。分別檢測(cè)兩組研究對(duì)象的血清UCH-L1和GFAP的表達(dá)水平。結(jié)果:UCH-L1診斷腦梗死的敏感度為75.0%,特異度為87.5%;GFAP診斷腦梗死的敏感度為81.3%,特異度為90.0%。UCH-L1和GFAP的受試者工作特征(receiver operating characteristic,ROC)曲線下面積分別為0.670及0.757。兩組研究對(duì)象在年齡、性別、飲酒、吸煙、糖尿病、高脂血癥等一般情況中比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05);觀察組患者患高血壓的比例明顯高于對(duì)照組(P0.05);經(jīng)Spearson/Pearson分析顯示血清UCH-L1與GFAP水平與高血壓呈正比,與性別、年齡、糖尿病、高血脂、飲酒、吸煙等因素?zé)o相關(guān)性;觀察組患者不同發(fā)病時(shí)間一般資料的比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05),血清UCH-L1和GFAP表達(dá)水平明顯高于對(duì)照組(P0.05);在不同發(fā)病時(shí)間兩組患者血清UCH-L1和GFAP表達(dá)水平差異無統(tǒng)計(jì)學(xué)意義(P0.05);輕、中、重型3組患者的血清UCH-L1和GFAP表達(dá)水平高于對(duì)照組(P0.05);中、重型患者血清UCH-L1和GFAP表達(dá)水平高于輕型(P0.05);觀察組患者在不同發(fā)病時(shí)間里血清UCH-L1和GFAP表達(dá)水平與梗死灶大小差異有統(tǒng)計(jì)學(xué)意義(P0.05);Pearson相關(guān)性分析結(jié)果示血清UCH-L1和GFAP表達(dá)水平呈正相關(guān)(r=0.634,P=0.001)。結(jié)論:在急性腦梗死患者中早期血清UCH-L1和GFAP的表達(dá)水平明顯升高,與腦梗死的病情嚴(yán)重程度有一定的相關(guān)性,可為臨床上早期診斷及治療提供依據(jù)。
[Abstract]:Objective: to observe the clinical expression levels of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and serum glial fibrillary acidic protein (GFAP) in patients with acute cerebral infarction (ACI), and to explore their clinical significance in patients with cerebral infarction. Methods: 80 patients with acute cerebral infarction treated in Chongqing Cancer Hospital from January 2014 to February 2016 were selected as the observation group and 80 healthy persons who came to the hospital for physical examination at the same time as the control group. The levels of serum UCH-L1 and GFAP were detected. Results the sensitivity of the diagnosis of cerebral infarction was 75.0, the specificity was 87.5 and the sensitivity of the GFAP was 81.3. The area under the receiver operating characteristic ROCcurve was 0.670 and 0.7577.The specificity was 90.0.UCH-L1 and GFAP respectively. Age, sex, alcohol consumption, smoking, diabetes, hyperlipidemia were compared between the two groups. There was no significant difference between the two groups (P 0.05), the proportion of patients with hypertension in the observation group was significantly higher than that in the control group (P 0.05), and the levels of serum UCH-L1 and GFAP were directly proportional to hypertension by Spearson / Pearson analysis, and were correlated with sex, age, diabetes, hyperlipidemia and alcohol consumption. There was no correlation between smoking and other factors. The levels of serum UCH-L1 and GFAP were significantly higher than those of the control group (P 0.05), and there was no significant difference in the levels of serum UCH-L1 and GFAP between the two groups at different time of onset (P 0.05). The levels of serum UCH-L1 and GFAP in the severe group were higher than those in the control group (P 0.05). The levels of serum UCH-L1 and GFAP in severe patients were higher than those in mild patients (P 0.05), and there was a significant difference between the levels of serum UCH-L1 and GFAP and infarct size in the observation group. The results of Pearson correlation analysis showed that the expression levels of serum UCH-L1 and GFAP were positively correlated with those of R0.634P0.001. Conclusion: the expression of UCH-L1 and GFAP in the early stage of acute cerebral infarction is significantly increased, which is related to the severity of cerebral infarction, and can provide evidence for early clinical diagnosis and treatment.
【作者單位】： 重慶市腫瘤研究所重慶市腫瘤醫(yī)院重慶市癌癥中心;新疆醫(yī)科大學(xué)第二附屬醫(yī)院;
【基金】：國(guó)家自然科學(xué)基金(U1503222)~~
【分類號(hào)】：R743.33

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