本文選題：左西孟坦注射液 + 無創(chuàng)呼吸機(jī)�。� 參考：《中國臨床藥理學(xué)雜志》2017年12期

【摘要】：目的觀察左西孟坦注射液聯(lián)合無創(chuàng)呼吸機(jī)治療老年急性心力衰竭的臨床療效及安全性。方法將162例老年急性心力衰竭患者隨機(jī)分為對照組81例和試驗(yàn)組81例。2組患者均予以無創(chuàng)呼吸機(jī)治療。在此基礎(chǔ)上,對照組予以鹽酸多巴酚丁胺注射液5μg·kg~(-1)·min~(-1),維持靜脈泵注24 h;試驗(yàn)組予以左西孟坦注射液12μg·kg~(-1)靜脈泵注10 min后,改為0.1μg·kg~(-1)·min~(-1)維持泵注24 h。2組患者均治療24 h。比較2組患者的臨床療效、心輸出量(CO)、心臟指數(shù)(CI)、心率,以及藥物不良反應(yīng)的發(fā)生情況。結(jié)果治療后,試驗(yàn)組和對照組的總有效率分別為96.29%(78/81例)和86.42%(70/81例),差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,試驗(yàn)組和對照組的CO分別為(2.33±0.33)和(1.79±0.24)L·min~(-1),CI分別為(3.23±0.46)和(2.35±0.32)L·min~(-1)·m~(-2),心率分別為(97.65±13.27)和(112.12±10.89)次/分,差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。試驗(yàn)組的藥物不良反應(yīng)主要有頭暈、血壓下降和胃腸脹氣,對照組的藥物不良反應(yīng)主要有頭暈和胃腸脹氣。試驗(yàn)組和對照組的藥物不良反應(yīng)發(fā)生率分別為13.58%和11.11%,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論左西孟坦注射液聯(lián)合無創(chuàng)呼吸機(jī)治療急性老年心力衰竭的臨床療效確切,其可顯著降低患者的心率,提高CO、CI水平,且不增加藥物不良反應(yīng)的發(fā)生率。
[Abstract]:Objective to observe the clinical efficacy and safety of levsimentan injection combined with non-invasive ventilator in the treatment of elderly patients with acute heart failure. Methods 162 elderly patients with acute heart failure were randomly divided into control group (81 cases) and experimental group (81 cases). On this basis, the control group was treated with dobutamine hydrochloride injection 5 渭 g / kg 路min ~ (-1) for 24 h, while the control group was treated with levsimentan injection (12 渭 g / kg) for 10 min and then changed to 0.1 渭 g 路kg ~ (-1) 路min ~ (-1) 路min ~ (-1). The clinical efficacy, cardiac output, cardiac index, heart rate and adverse drug reactions were compared between the two groups. Results after treatment, the total effective rates of the test group and the control group were 96.29 / 78 / 81 and 86.42 / 70 / 81, respectively. The difference was statistically significant (P 0.05). After treatment, the CO values of the experimental group and the control group were 2.33 鹵0.33) and 1.79 鹵0.24 L / min respectively, the CI were 3.23 鹵0.46) and 2.35 鹵0.32 L / min respectively. The heart rate was 97.65 鹵13.27 and 112.12 鹵10.89 / min, respectively. The main adverse drug reactions in the test group were dizziness, decreased blood pressure and flatulence, while in the control group the main adverse drug reactions were dizziness and flatulence. The incidence of adverse drug reactions in the test group and the control group were 13.58% and 11.11%, respectively, with no significant difference (P 0.05). Conclusion the clinical effect of levoximentam injection combined with noninvasive ventilator in the treatment of acute senile heart failure is definite. It can significantly reduce the heart rate, increase the level of COOCI, and do not increase the incidence of adverse drug reactions.
【作者單位】： 鄭州大學(xué)附屬醫(yī)院南陽市中心醫(yī)院重癥醫(yī)學(xué)科;鄭州大學(xué)附屬醫(yī)院南陽市中心醫(yī)院內(nèi)分泌科;鄭州大學(xué)附屬醫(yī)院南陽市中心醫(yī)院消化科;
【基金】：河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃基金資助項(xiàng)目(122300410028)
【分類號】：R541.6

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