本文選題：急性腦梗死 + 前列地爾��； 參考：《中國藥房》2016年26期

【摘要】：目的:探討早期使用前列地爾治療急性腦梗死的療效,及其對(duì)患者血漿正五聚體蛋白(PTX)3、腎功能與頸動(dòng)脈斑塊穩(wěn)定性的影響。方法:選取我院2011年8月-2015年8月收治的急性腦梗死患者93例,根據(jù)就診順序進(jìn)行編號(hào),并按照就診順序單雙號(hào)依次納入觀察組(47例,2例病例脫落,共45例完成研究)和對(duì)照組(46例,1例病例脫落,共45例完成研究)。對(duì)照組患者給予胞磷膽堿鈉注射液0.5 g~+銀杏葉提取物注射液20 ml加入0.9%氯化鈉注射液(NS)250 ml中,ivgtt,qd;觀察組患者在此基礎(chǔ)上給予前列地爾注射液20μg加入NS 250 ml中,ivgtt,qd。兩組患者療程均為2周。觀察兩組患者的臨床療效,治療前后PTX-3、血尿素氮(BUN)、血清肌酐(SCr)、24 h尿蛋白定量(Upro)、頸動(dòng)脈斑塊穩(wěn)定性的差異以及不良反應(yīng)發(fā)生情況。結(jié)果:觀察組患者總有效率(91.1%)明顯高于對(duì)照組(73.3%),差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療前,兩組患者PTX-3、BUN、SCr和24 h Upro比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,兩組患者PTX-3、BUN、SCr和24 h Upro均明顯降低,且觀察組患者明顯低于對(duì)照組;觀察組患者斑塊穩(wěn)定性(100.0%)亦明顯高于對(duì)照組(64.0%),差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組患者出現(xiàn)的不良反應(yīng)未進(jìn)行特殊處理均自行緩解,且差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:早期使用前列地爾治療急性腦梗死療效較好,可明顯降低患者PTX-3,改善腎功能,提高頸動(dòng)脈斑塊穩(wěn)定性,且安全性較好。
[Abstract]:Objective: to investigate the effect of early use of alprostadil on acute cerebral infarction and its effects on plasma pentagglutinin (PTX3), renal function and carotid plaque stability. Methods: 93 patients with acute cerebral infarction admitted in our hospital from August 2011 to August 2015 were selected and numbered according to the order of visit. According to the order of visit, 47 patients with acute cerebral infarction in the observation group were included in the observation group. A total of 45 cases completed the study) and the control group of 46 cases (1 case) dropped off, a total of 45 cases completed the study. The patients in the control group were given citicoline sodium injection 0.5 g ~ Ginkgo biloba extract injection 20 ml, and the patients in the observation group were given 20 渭 g alprostadil injection added to NS 250 ml iv gttt QD in 0.9% sodium chloride injection NS250 ml, and the patients in the observation group were given alprostadil injection 20 渭 g plus NS 250 ml iv gttt QD. The course of treatment was 2 weeks. The clinical efficacy, PTX-3, blood urea nitrogen bun, serum creatinine, 24 h urinary protein, carotid plaque stability and the occurrence of adverse reactions were observed. Results: the total effective rate of patients in the observation group (91.1%) was significantly higher than that in the control group (73.3%), and the difference was statistically significant (P 0.05). Before treatment, there was no significant difference between the two groups in PTX-3 bun SCR and 24 h Upro (P 0.05). After treatment, the levels of PTX-3 bun SCR and 24 h Upro in the observation group were significantly lower than those in the control group, and the plaque stability in the observation group was significantly higher than that in the control group (P 0.05). The adverse reactions of the two groups were not relieved by special treatment, and the difference was not statistically significant (P 0.05). Conclusion: early use of alprostadil in the treatment of acute cerebral infarction can significantly reduce PTX-3, improve renal function, improve the stability of carotid plaque, and the safety is good.
【作者單位】： 無錫市第二人民醫(yī)院神經(jīng)內(nèi)科;
【分類號(hào)】：R743

【相似文獻(xiàn)】

相關(guān)會(huì)議論文 前10條

1 黃菊明;;探討神經(jīng)元特異性烯醇化酶在急性腦梗死患者中的臨床價(jià)值[A];2007年浙江省神經(jīng)病學(xué)學(xué)術(shù)年會(huì)論文匯編[C];2007年

2 張?jiān)蕩X;;急性腦梗死毒損腦絡(luò)學(xué)說基礎(chǔ)與臨床研究進(jìn)展[A];第二屆中西醫(yī)結(jié)合腦病診治新進(jìn)展高級(jí)研討班專家講義及論文匯編[C];2010年

3 毛銳;聶志余;靳令經(jīng);封亮;陳玉輝;李云霞;;頸動(dòng)脈粥樣硬化性狹窄或閉塞所致急性腦梗死類型研究[A];中華醫(yī)學(xué)會(huì)第十三次全國神經(jīng)病學(xué)學(xué)術(shù)會(huì)議論文匯編[C];2010年

4 張小雨;張鳳;王棟;張媛媛;李曉紅;;急性腦梗死后血糖水平與輕度認(rèn)知功能損害關(guān)系研究[A];2011全國老年癡呆與衰老相關(guān)疾病學(xué)術(shù)會(huì)議第三屆山東省神經(jīng)內(nèi)科醫(yī)師（學(xué)術(shù)）論壇論文匯編[C];2011年

5 耿亞蘭;鐘傳林;楊清樺;;急性腦梗死患者超敏C-反應(yīng)蛋白監(jiān)測(cè)的臨床意義[A];貴州省醫(yī)學(xué)會(huì)第八屆神經(jīng)病學(xué)年會(huì)論文集[C];2010年

6 孫延文;;克栓酶兩種劑量治療急性腦梗死患者的療效觀察及護(hù)理[A];全國神經(jīng)內(nèi)、外科�？谱o(hù)理學(xué)術(shù)會(huì)議論文匯編[C];2002年

7 趙路清;崔愛勤;劉錦峰;張運(yùn)生;王惠聰;郭學(xué)英;劉改生;郭志昌;;不同劑量金爾倫治療急性腦梗死的臨床研究[A];中華醫(yī)學(xué)會(huì)第七次全國神經(jīng)病學(xué)學(xué)術(shù)會(huì)議論文匯編[C];2004年

8 吳云成;趙永波;談?dòng)阑?喬健;呂傳真;;血清神經(jīng)元特異性烯醇化酶與急性腦梗死患者遠(yuǎn)期預(yù)后的相關(guān)性研究[A];中華醫(yī)學(xué)會(huì)第七次全國神經(jīng)病學(xué)學(xué)術(shù)會(huì)議論文匯編[C];2004年

9 劉軍;富昭;魚博浪;張明;丁暉;吳蘭琴;邵瑩;劉慶祿;;氫質(zhì)子磁共振波譜在急性腦梗死診斷中的價(jià)值[A];人體斷面數(shù)據(jù)獲取與圖像處理研討會(huì)論文匯編[C];2005年

10 蘇慶杰;陳志斌;蔡美華;王W，

本文編號(hào)：1854231