發(fā)布時(shí)間：2018-05-03 08:12

  本文選題：氨甲環(huán)酸 + 創(chuàng)傷性凝血病�。� 參考：《中國(guó)現(xiàn)代醫(yī)學(xué)雜志》2017年24期

【摘要】：目的探討氨甲環(huán)酸對(duì)創(chuàng)傷性凝血病患者的臨床療效及作用機(jī)制。方法選取2015年4月-2016年6月就診于該院的創(chuàng)傷性凝血病患者106例,根據(jù)隨機(jī)數(shù)表法原則將所有患者分為兩組,各53例。對(duì)照組采用常規(guī)療法,如手術(shù)止血、輸注血制品及補(bǔ)充鈣質(zhì)。觀察組在此基礎(chǔ)上加用氨甲環(huán)酸治療。比較兩組治療指標(biāo)、炎癥因子水平、血制品輸注量及預(yù)后。結(jié)果觀察組凝血酶原時(shí)間(PT)、活化部分凝血或酶時(shí)間(APTT)及纖維蛋白原(Fbg)等指標(biāo)改善情況優(yōu)于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);觀察組腫瘤壞死因子α(TNF-α)等炎癥因子水平低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);觀察組血制品輸用量少于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);觀察組預(yù)后情況優(yōu)于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論氨甲環(huán)酸治療創(chuàng)傷性凝血病效果顯著,能夠減少出血量,改善患者凝血功能,降低炎癥反應(yīng),有助于改善預(yù)后。
[Abstract]:Objective to investigate the clinical effect and mechanism of methacylic acid in patients with traumatic coagulation disease. Methods 106 patients with traumatic coagulation were selected from April 2015 to June 2016. According to the principle of random number table, all patients were divided into two groups, 53 cases in each group. The control group was treated with routine therapy, such as surgical hemostasis, transfusion of blood products and calcium supplement. On this basis, the observation group was treated with methachloroic acid. The treatment index, inflammatory factor level, blood product infusion volume and prognosis were compared between the two groups. Results the changes of prothrombin time (PTT), activated partial coagulation (APTT) and fibrinogen (Fbg) in the observation group were better than those in the control group (P 0.05), and the levels of inflammatory factors such as tumor necrosis factor 偽 (TNF- 偽) in the observation group were lower than those in the control group. The difference was statistically significant (P 0.05); the dosage of blood products in the observation group was less than that in the control group (P 0.05); the prognosis of the observation group was better than that in the control group (P 0.05). Conclusion the treatment of traumatic thromboplasmosis with carbamoic acid is effective, which can reduce the amount of blood loss, improve the blood coagulation function, reduce the inflammatory reaction, and improve the prognosis.
【作者單位】： 河北省石家莊市第三醫(yī)院急診科;
【基金】：石家莊市科學(xué)技術(shù)研究與發(fā)展指導(dǎo)計(jì)劃(No:151460773)
【分類(lèi)號(hào)】：R641

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