本文選題：七氟烷 + 環(huán)境低溫��； 參考：《沈陽藥科大學學報》2016年09期

【摘要】：目的探討七氟烷對低溫環(huán)境下失血性休克豬的心肌保護作用。方法巴馬小型豬32頭,雌雄不限,體質(zhì)量20~25 kg,按隨機數(shù)字表法分為4組,每組8頭。分別為假手術(shù)組(S組)、失血性休克組(HS組)、七氟烷預(yù)處理組(Pre/Sev組)和七氟烷后處理組(Post/Sev組)。監(jiān)測并記錄各組平均動脈壓、心率和中心體溫,各組分別于休克前及休克后30、60、90、120、180和240 min共7個時間點采集血液,采用ELISA法檢測血清中白細胞介素-6(interleukin 6,IL-6)、腫瘤壞死因子-α(tumour necrosis factorα,TNF-α)和超氧化物歧化酶(superoxide dismutase,SOD)的含量。結(jié)果與S組比較,HS組、Pre/Sev組和Post/Sev組血漿中TNF-α和IL-6含量在休克后60 min和90 min顯著升高(P0.05),其中TNF-α含量在休克120 min時達到高峰,休克180 min時顯著低于120 min(P0.05);血清中SOD含量顯著降低(P0.05)。與HS組比較,Pre/Sev組和Post/Sev組血漿中TNF-α和IL-6含量顯著降低(P0.05);血清中SOD含量顯著升高(P0.05)。Pre/Sev組和Post/Sev組各項比較差異無顯著意義(P0.05)。結(jié)論七氟烷對低溫環(huán)境下失血性休克豬心肌具有保護作用,其主要機制與抑制炎癥反應(yīng),增強機體抗氧化能力有關(guān)。
[Abstract]:Objective to investigate the myocardial protective effect of seven Fluoroalkane on hemorrhagic shock pigs in low temperature environment. Methods 32 Bama miniature pigs, male and female, body mass 20~25 kg, were divided into 4 groups according to random digital table method, each group was sham operation group (group S), hemorrhagic shock group (group HS), seven fluorane preconditioning group (Pre/Sev group) and seven halothane post treatment group (Post/Se The mean arterial pressure, heart rate and central body temperature were monitored and recorded in each group. The blood was collected at 7 time points before shock and after shock, 30,60,90120180 and 240 min, respectively. The serum interleukin -6 (interleukin 6, IL-6), tumor necrosis factor alpha (tumour necrosis factor A, TNF- alpha) and superoxide dismutation were detected by ELISA method. The content of the enzyme (superoxide dismutase, SOD). Compared with the S group, the levels of TNF- A and IL-6 in the plasma of HS, Pre/Sev and Post/Sev significantly increased (P0.05) in the 60 min and 90 min after shock, and the content of the alpha content reached a peak at 120 of shock and was significantly lower than 120 when the shock was 180. Compared with group S, the plasma level of TNF- alpha and IL-6 in Pre/Sev and Post/Sev groups decreased significantly (P0.05), and the content of SOD in serum increased significantly (P0.05) in.Pre/Sev group and Post/Sev group, and there was no significant difference (P0.05). Conclusion seven Fluoroalkane has protective effect on porcine myocardium with hemorrhagic shock in low temperature environment, and its main mechanism is to inhibit inflammation, To enhance the body's antioxidant capacity.

【作者單位】： 遼寧醫(yī)學院沈陽軍區(qū)總醫(yī)院研究生培養(yǎng)基地;沈陽軍區(qū)總醫(yī)院麻醉科;
【基金】：軍隊后勤科研重點資金資助項目(BWS12J008)
【分類號】：R459.7

【相似文獻】

相關(guān)期刊論文 前10條

1 楊小霖;Edmond Eger;Manohar Sharma;;七氟烷在小鼠中的代謝研究[J];四川醫(yī)學;2012年11期

2 李麗;呂國義;鄧^，

本文編號：1837225