本文選題：丘腦 + 局部一致性��； 參考：《中國科學(xué)技術(shù)大學(xué)》2015年碩士論文

【摘要】：本篇畢業(yè)論文用靜息態(tài)功能磁共振成像數(shù)據(jù)研究了急性腦卒中后皮質(zhì)-丘腦-皮質(zhì)環(huán)路在皮層功能重構(gòu)過程中的作用。之前的很多研究已經(jīng)發(fā)現(xiàn)腦卒中后的運動恢復(fù)和皮層功能重構(gòu)相關(guān)而且腦卒中后運動功能的恢復(fù)中會有丘腦激活情況的變化。而丘腦可以通過皮質(zhì)-丘腦-皮質(zhì)環(huán)路來調(diào)節(jié)各個皮層區(qū)域之間的激活。為了研究腦卒中后皮層功能重組是否和皮質(zhì)-丘腦-皮質(zhì)環(huán)路有關(guān),本研究把腦卒中被試分為兩個組：UP group-皮質(zhì)-丘腦-皮質(zhì)環(huán)路正常的病人(即從丘腦傳出的信息流正常,共16個腦卒中被試)；DOWN group-皮質(zhì)-丘腦-皮質(zhì)環(huán)路受損病人(即從丘腦傳出的信息流受損,共10個腦卒中被試)。然后,我們采集了靜息態(tài)功能磁共振數(shù)據(jù)來研究了兩組病人和正常對照組(H group,共招募了19名正常健康被試)的大腦局部一致性。我們的結(jié)果發(fā)現(xiàn),和健康對照組相比,UP group在雙側(cè)丘腦和記憶相關(guān)的腦區(qū)：雙側(cè)海馬旁回的局部一致性顯著增加,在感覺系統(tǒng)的輸入和整合相關(guān)的腦區(qū)：左側(cè)楔前葉／楔葉和左側(cè)顳中回的局部一致性顯著降低。而和健康對照組相比,DOWN group只在雙側(cè)楔葉／楔前葉和右側(cè)頂下小葉局部一致性顯著降低而沒有腦區(qū)有顯著增強(qiáng)的局部一致性。此外,在UP group中左側(cè)丘腦和左內(nèi)側(cè)額葉、右側(cè)梭狀回和右側(cè)顳中回之間的功能連接比H group要高,而在DOWN group中只發(fā)現(xiàn)左側(cè)丘腦和左內(nèi)側(cè)額葉之間的功能連接增高。并且和H group比,不論UP group還是DOWN group都沒有發(fā)現(xiàn)大腦拓?fù)浣Y(jié)構(gòu)的改變。我們的結(jié)果暗示由于腦卒中導(dǎo)致的軀體感覺系統(tǒng)的受損而在記憶系統(tǒng)發(fā)生的補(bǔ)償作用僅僅發(fā)生在從丘腦傳出的信息流正常沒有受損的腦卒中病人上,而且這種效應(yīng)可能影響的是一種特定的丘腦網(wǎng)絡(luò)而不是全腦的大腦功能網(wǎng)絡(luò)。結(jié)論：總的來說,我們的結(jié)果暗示當(dāng)腦卒中病人的皮質(zhì)-丘腦-皮質(zhì)環(huán)路沒有受損的時候會發(fā)生更好的腦卒中后皮層功能重構(gòu)而且這種效應(yīng)可能影響的是一種特定的丘腦網(wǎng)絡(luò)而不是全腦的大腦功能網(wǎng)絡(luò)。這一結(jié)果暗示皮質(zhì)-丘腦-皮質(zhì)環(huán)路可能在腦卒中后皮層功能重組中非常重要。我們的研究中采用的分類方法可能提供了一個新的研究思路。另外皮質(zhì)-丘腦-皮質(zhì)環(huán)路在皮層功能重組中可能的重要作用可以為臨床上的腦卒中后康復(fù)提供一個新的方向。
[Abstract]:The role of cortex-thalamic-cortical loop in cortical functional remodeling after acute stroke was studied using resting functional magnetic resonance imaging (fMRI) data. Many previous studies have found that motor recovery after stroke is associated with cortical functional remodeling and that there are changes in thalamic activation in the recovery of motor function after stroke. The thalamus can regulate the activation of various cortical regions through the cortical-thalamic-cortical loop. In order to study whether the functional recombination of the cortex after stroke is related to the cortex-thalamus-cortical loop, the subjects were divided into two groups: the normal flow of information from the thalamus. A total of 16 stroke subjects were involved in the impaired DOWN group- cortex-thalamo-cortical loop (i.e., the information flow from the thalamus was impaired, and 10 stroke subjects were involved. Then we collected resting functional magnetic resonance data to study the local consistency of brain in two groups of patients and a control group of 19 healthy subjects. Our results showed that the local consistency of up group in bilateral thalamic and memory-related brain regions was significantly increased compared with that in healthy controls. In the sensory system input and integration-related areas: the local consistency of the left anterior cuneiform / cuneate lobe and left middle temporal gyrus decreased significantly. Compared with the healthy control group, the local consistency of don group in bilateral cuneiform / precuneiform lobe and right inferior parietal lobule was significantly lower than that in the control group, but there was no significant enhancement of local consistency in the brain region. In addition, the functional junctions between left thalamus and left medial frontal lobe, right fusiform gyrus and right middle temporal gyrus in up group were higher than those in H group, but in DOWN group only the functional connections between left thalamus and left medial frontal lobe were increased. Compared with H group, neither up group nor DOWN group found any changes in brain topology. Our results suggest that the compensatory effect of the memory system on the memory system due to the impairment of the somatosensory system caused by stroke occurs only in stroke patients whose flow of information from the thalamus is normal and not impaired. And this effect may affect a specific thalamic network rather than the brain function network of the whole brain. Conclusion: in general, Our results suggest that better cortical remodeling occurs when the cortex-thalamus-cortical loop is not impaired in stroke patients and that this effect may affect a specific thalamic network rather than a It's a network of brain functions throughout the brain. The results suggest that the cortical-thalamic-cortical loop may be important in the reconstitution of cortical function after stroke. The classification method used in our study may provide a new approach to research. In addition, the cortex-thalamic-cortical loop may play an important role in cortical functional reorganization, which may provide a new direction for clinical rehabilitation after stroke.
【學(xué)位授予單位】：中國科學(xué)技術(shù)大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R743.3

【參考文獻(xiàn)】

相關(guān)期刊論文 前9條

1 王立波;;康復(fù)治療的早期介入對腦卒中的療效分析[J];中國社區(qū)醫(yī)師;2009年15期

2 鄧永萍;姚子弘;鄭凱雙;;偏癱患者不同時期康復(fù)訓(xùn)練的效果比較[J];實用醫(yī)學(xué)雜志;2009年10期

3 楊青蘭;高曉艷;林海;代濤;;康復(fù)治療對不同階段腦卒中患者運動功能影響的研究[J];河北醫(yī)藥;2006年06期

4 李浩,張家良,楊茂軒,胡法富;早期康復(fù)對急性腦卒中的臨床療效[J];中國康復(fù);2004年04期

5 方華,周志賢,劉桂芬;功能性電刺激輔助干預(yù)腦卒中患者運動功能恢復(fù)的作用[J];中國臨床康復(fù);2004年16期

6 曾憲聰,秦鵬明,盧秀蓮;腦卒中患者早期康復(fù)的預(yù)后研究[J];現(xiàn)代醫(yī)藥衛(wèi)生;2004年09期

7 胡建民,王中峰,郭華;早期康復(fù)干預(yù)對急性腦卒中患者心理與日常生活活動能力的影響[J];中國臨床康復(fù);2003年10期

8 藺勇,殷淑萍,李艷,裴明正;康復(fù)的早期介入對腦卒中患者日常生活活動能力的影響[J];中風(fēng)與神經(jīng)疾病雜志;2003年01期

9 謝淑萍,趙立杰,劉清;腦卒中對患者生活質(zhì)量影響的分析[J];神經(jīng)疾病與精神衛(wèi)生;2001年02期

，

本文編號：1784432