本文選題：多器官功能損傷 + 圍生期窒息��； 參考：《山東大學(xué)學(xué)報(醫(yī)學(xué)版)》2016年09期

【摘要】：目的探討不同胎齡圍生期窒息與多器官功能損傷(MODS)的相關(guān)性。方法收集山東大學(xué)附屬濟(jì)南市中心醫(yī)院產(chǎn)科有窒息高危因素的新生兒165例,根據(jù)臍動脈血?dú)夥治鼋Y(jié)果及Apgar評分判斷有無圍生期窒息,將其分為早產(chǎn)窒息組、足月窒息組、早產(chǎn)對照組、足月對照組,比較各組MODS的發(fā)生率。165例中發(fā)生圍生期窒息的新生兒有79例,根據(jù)胎齡將其分為早期早產(chǎn)窒息組、晚期早產(chǎn)窒息組、足月窒息組,比較各組窒息后MODS的嚴(yán)重程度;根據(jù)窒息程度分為輕度窒息組、重度窒息組,比較兩組MODS的發(fā)生率及嚴(yán)重程度。結(jié)果早產(chǎn)窒息組MODS發(fā)生率高于足月兒窒息組(χ~2=5.37,P0.05)。窒息后MODS嚴(yán)重程度:早期早產(chǎn)窒息組、晚期早產(chǎn)窒息組、足月窒息組比較差異有統(tǒng)計(jì)學(xué)意義(χ~2=6.11,P0.05),胎齡與M ODS的發(fā)生率呈正相關(guān)性(r=0.29),胎齡與窒息后MODS程度呈正相關(guān)性(r=0.35);輕度窒息組與重度窒息組MODS發(fā)生率差異有統(tǒng)計(jì)學(xué)意義(χ~2=9.30,P0.05),輕度窒息組與重度窒息組MODS嚴(yán)重程度差異有統(tǒng)計(jì)學(xué)意義(χ~2=6.80,P0.05)。結(jié)論早產(chǎn)兒圍生期窒息后發(fā)生MODS的風(fēng)險高于足月兒;胎齡越小,窒息后MODS的發(fā)生率越高、程度越重;圍生期窒息越重,MODS的發(fā)生率越高、程度越嚴(yán)重。
[Abstract]:Objective to investigate the relationship between perinatal asphyxia and multiple organ function injury (MODS) at different gestational ages. Methods 165 neonates with high risk factors of asphyxia were collected from Jinan Central Hospital affiliated to Shandong University. According to the results of umbilical artery blood gas analysis and Apgar score, the neonates were divided into premature asphyxia group and term asphyxia group. There were 79 cases of perinatal asphyxia in each group. According to gestational age, they were divided into early premature asphyxia group, late premature birth asphyxia group, term asphyxia group, and term asphyxia group. The severity of MODS after asphyxia was compared, and according to the degree of asphyxia, the incidence and severity of MODS were compared between mild asphyxia group and severe asphyxia group. Results the incidence of MODS in premature asphyxia group was higher than that in term asphyxia group (蠂 ~ (2) 5.37) (P0.05). MODS severity after asphyxia: early premature asphyxia group, late premature birth asphyxia group, There was a significant difference in term asphyxia group (蠂 ~ 2 / 2 ~ (6.11) P _ (0.05)), gestational age and M _ (ODS) incidence were positively correlated, gestational age had a positive correlation with MODS degree after asphyxia, and there was a significant difference between mild asphyxia group and severe asphyxia group (蠂 ~ (29.30) P _ (0.05), P < 0.05). There was significant difference in MODS severity between mild asphyxia group and severe asphyxia group. Conclusion the risk of MODS in premature infants after perinatal asphyxia is higher than that in term infants; the lower the gestational age, the higher the incidence and severity of MODS after asphyxia, and the higher the incidence and severity of mods in perinatal asphyxia.
【作者單位】： 泰山醫(yī)學(xué)院研究生院;山東大學(xué)附屬濟(jì)南市中心醫(yī)院兒科;
【基金】：山東省科技發(fā)展計(jì)劃(2013GSF11868)
【分類號】：R714.7;R459.7

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