本文選題：肝功能衰竭 + 磁共振成像�。� 參考：《中國(guó)醫(yī)學(xué)影像技術(shù)》2017年06期

【摘要】：目的探討肝臟T2值對(duì)HBV相關(guān)慢加急性肝衰竭的評(píng)估價(jià)值。方法收集HBV相關(guān)慢加急性肝衰竭(HBV-ACLF)組、慢性乙型肝炎組和正常對(duì)照組,分別對(duì)3組受檢者行多回波梯度—自旋回波(M-GRASE)序列掃描,獲得T2圖,并計(jì)算肝臟平均T2值及T2弛豫率(R2)。收集HBV-ACLF組和慢性乙型肝炎組MR檢查前2天內(nèi)肝功能血液生化指標(biāo)。比較3組間T2和R2值的差異及T2值與生化指標(biāo)的相關(guān)性,采用ROC曲線評(píng)價(jià)T2值對(duì)HBV-ACLF的診斷效能。結(jié)果 3組間T2值(χ2=19.074,P0.001)和R2值(F=10.411,P0.001)差異均有統(tǒng)計(jì)學(xué)意義。T2值診斷慢加急性肝衰竭曲線下面積為0.86(P0.001),診斷閾值為57.73ms(R2=0.017)。T2值與凝血酶原時(shí)間國(guó)際標(biāo)準(zhǔn)化比值(INR)、凝血酶原時(shí)間(PT)及透明質(zhì)酸(HA)呈中度正相關(guān)(rs=0.65、0.67、0.39,P均0.05),與凝血酶原活動(dòng)度(PTA)、白蛋白(ALB)、前白蛋白(PA)呈中度負(fù)相關(guān)(rs=-0.67、-0.48、-0.37,P均0.05)。結(jié)論 T2或R2值可較好地反映肝臟功能情況,并與較多的肝功能實(shí)驗(yàn)室指標(biāo)均具有相關(guān)性,對(duì)HBV-ACLF具有較好的診斷效能。
[Abstract]:Objective to evaluate the value of liver T 2 value in HBV associated chronic and acute hepatic failure.Methods the patients in HBV associated chronic and acute hepatic failure group, chronic hepatitis B group and normal control group were scanned with multi-echo gradient-spin echo M-GRASE sequence, respectively. The T 2 images were obtained, and the mean T 2 value and T 2 relaxation rate of liver were calculated.The blood biochemical indexes of liver function in HBV-ACLF group and chronic hepatitis B group were collected 2 days before Mr examination.The difference of T2 and R2 between the three groups and the correlation between T2 and biochemical indexes were compared. The ROC curve was used to evaluate the diagnostic efficacy of T2 for HBV-ACLF.Results there were significant differences among the three groups in T2 value (蠂 2 + 19.074U P 0.001) and R2 value (P 0.001). The area under the curve of slow diagnosis and acute hepatic failure was 0.86% P0.001.The diagnostic threshold was INRR, prothrombin time and prothrombin time ratio (INRR) and prothrombin time (PTT).Hyaluronic acid (HA) showed moderate positive correlation with prothrombin activity (PTAA), Albumin (Alb) and prealbumin (PAA), and was negatively correlated with the prothrombin activity (PTAA), prothrombin activity (Alb), and prealbumin (PAA), and was negatively correlated with the prothrombin activity (PTAA), prothrombin activity (Alb), and prealbumin (PAA) (P < 0. 05, P = 0. 05, P = 0. 05).Conclusion T2 or R2 values can better reflect the liver function, and are correlated with more laboratory indexes of liver function. It has good diagnostic efficacy for HBV-ACLF.
【作者單位】： 西南醫(yī)科大學(xué)附屬醫(yī)院放射科;西南醫(yī)科大學(xué)附屬醫(yī)院傳染消化科;
【分類(lèi)號(hào)】：R445.2;R512.62;R575.3

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