本文選題：急性腦梗死 + 簇集蛋白�。� 參考：《重慶醫(yī)學(xué)》2016年21期

【摘要】：目的探討簇集蛋白(CLU)在急性腦梗死(ACI)中的表達(dá)及其臨床意義。方法選取2013年5~12月于南昌大學(xué)第一附屬醫(yī)院住院(首次發(fā)病48h內(nèi))的ACI患者154例作為ACI組,根據(jù)神經(jīng)功能缺損程度、有無斑塊進(jìn)行亞分組,另選取45例同期體檢健康者作為對(duì)照組,檢測血清CLU、補(bǔ)體C3水平,進(jìn)行美國國立衛(wèi)生院神經(jīng)功能缺損評(píng)分(NIHSS)及Barthel指數(shù)評(píng)定,隨訪康復(fù)經(jīng)過及結(jié)局至發(fā)病后90d,比較分析血清CLU水平。結(jié)果 ACI組患者血清CLU、補(bǔ)體C3水平均較對(duì)照組增高,差異均有統(tǒng)計(jì)學(xué)意義(P0.01),且ACI患者血清CLU與補(bǔ)體C3水平呈正相關(guān)(r=0.430,P=0.000)。有斑塊、神經(jīng)功能缺損程度重的患者血清CLU水平高于無斑塊、神經(jīng)功能缺損程度輕的患者,差異均有統(tǒng)計(jì)學(xué)意義(P0.01或P0.05)。除痊愈與顯效患者血清CLU水平比較差異無統(tǒng)計(jì)學(xué)意義(P0.05),其余各預(yù)后類型患者血清CLU水平比較,差異均有統(tǒng)計(jì)學(xué)意義(P0.01或P0.05),血清CLU水平越低患者康復(fù)情況越好。結(jié)論 CLU在腦梗死發(fā)生后可調(diào)節(jié)補(bǔ)體系統(tǒng)發(fā)揮作用,血清CLU水平與ACI患者頸動(dòng)脈斑塊、神經(jīng)功能缺損程度及預(yù)后均相關(guān),可作為ACI患者病情評(píng)估及指導(dǎo)預(yù)后的生化指標(biāo)之一。
[Abstract]:Objective to investigate the expression and clinical significance of cluster protein (CLU) in acute cerebral infarction (ACI).Methods 154 ACI patients who were hospitalized in the first affiliated Hospital of Nanchang University from May to December 2013 (within 48 hours of first onset) were selected as ACI group.In addition, 45 healthy subjects were selected as control group. Serum CLU and complement C3 levels were measured, and the neurological impairment score (NIH) and Barthel index were evaluated.The patients were followed up to 90 days after onset and the serum CLU levels were compared and analyzed.Results the levels of serum CLU and C3 in ACI group were significantly higher than those in control group (P 0.01). There was a positive correlation between serum CLU and complement C3 levels in ACI patients.The serum CLU levels in patients with plaque and severe neurological impairment were significantly higher than those without plaque and mild neurological impairment (P 0.01 or P 0.05).There was no significant difference in serum CLU level between cured patients and patients with marked effect (P 0.05), but there were significant differences in serum CLU levels between patients with different prognostic types (P 0.01 or P 0.05). The lower the serum CLU level was, the better the recovery was.Conclusion CLU can regulate the complement system after cerebral infarction. The level of serum CLU is correlated with the degree of carotid plaque, nerve function defect and prognosis in patients with ACI. It can be used as one of the biochemical indexes to evaluate and guide the prognosis of patients with ACI.
【作者單位】： 江西省宜春市人民醫(yī)院干部綜合病房;南昌大學(xué)第一附屬醫(yī)院神經(jīng)內(nèi)科;
【分類號(hào)】：R743.3
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本文編號(hào)：1752631