本文選題：心肌損傷　切入點(diǎn)：一氧化碳中毒　出處：《東南大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年03期

【摘要】：目的:探討急性一氧化碳(CO)中毒后心臟損傷及其臨床治療方案。方法:收集我院收治的200例急性CO中毒后出現(xiàn)心臟損傷患者,按照隨機(jī)對(duì)照原則分為卡托普利常規(guī)治療的對(duì)照組和在常規(guī)治療基礎(chǔ)上加用輔酶Q10膠囊的實(shí)驗(yàn)組各100例;療程12周,兩組患者治療6、12周后復(fù)查超聲心動(dòng)圖與心電圖、超敏C反應(yīng)蛋白(hs-CRP)、腦鈉肽(pro-BNP)、肌酸激酶同工酶(CK-MB)、肌鈣蛋白(cTnI)等水平。結(jié)果:治療6周后,實(shí)驗(yàn)組患者的CK-MB水平明顯低于對(duì)照組(P=0.002);治療12周后,實(shí)驗(yàn)組LVEDD、LVESD較對(duì)照組明顯降低,而LVEF明顯增高(P=0.001);治療12周后,實(shí)驗(yàn)組pro-BNP、cTnI及CRP水平明顯低于對(duì)照組(P=0.001、0.002、0.001)。結(jié)論:對(duì)急性CO中毒后心肌損傷患者,聯(lián)合使用輔酶Q10膠囊與卡托普利可以有效抑制心臟惡性重塑,抑制缺氧引起的心肌損害,改善左心室收縮功能。
[Abstract]:Objective: to investigate the cardiac injury after acute carbon monoxide (CO) poisoning and its clinical treatment. Methods: 200 patients with cardiac injury after acute CO poisoning were collected in our hospital. According to the principle of random control, the two groups were divided into two groups: the control group treated with captopril and the experimental group treated with coenzyme Q10 capsule on the basis of routine treatment, the course of treatment was 12 weeks, and the echocardiography and electrocardiogram were reexamined after 6 weeks of treatment in both groups. Results: after 6 weeks of treatment, the CK-MB level of the patients in the experimental group was significantly lower than that in the control group, and after 12 weeks of treatment, the LVEDDLVESD in the experimental group was significantly lower than that in the control group, and after 12 weeks of treatment, the level of LVEDDLVESD in the experimental group was significantly lower than that in the control group. After 12 weeks of treatment, the levels of pro-BNPN cTnI and CRP in the experimental group were significantly lower than those in the control group. Conclusion: the combination of coenzyme Q10 capsule and captopril can effectively inhibit the malignant remodeling of the heart after acute CO poisoning in patients with myocardial injury. Inhibit myocardial damage caused by hypoxia and improve left ventricular systolic function.
【作者單位】： 唐山市工人醫(yī)院超聲科;唐山市工人醫(yī)院老年病科;
【分類號(hào)】：R595.1

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