本文關(guān)鍵詞： 心型脂肪酸結(jié)合蛋白 急性心肌梗死 冠脈狹窄程度　出處：《新疆醫(yī)科大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：探討血清心型脂肪酸結(jié)合蛋白(H-FABP)的濃度在急性心肌梗死患者早期評估冠脈病變程度的意義及應(yīng)用價值。方法：選取2012年12月至2013年12月就診于新疆醫(yī)科大學(xué)第一附屬醫(yī)院急診科的急性心肌梗死患者122例作為病例組,同時選取相同時間段就診該院體檢科患者50人作為對照組。檢測其血清CK、CK-MB、TnT的濃度,同時運用ReLIA多功能免疫檢測儀器檢測其心型脂肪酸結(jié)合蛋白血清濃度。分析上述指標(biāo)與冠脈病變程度的關(guān)系。冠依據(jù)狀動脈造影結(jié)果分類：單支病變組病變累及1支患者47例。病變累及2支患者44例。病變累及2支以上患者31例。冠狀動脈病變狹窄直徑在50%～70%之間的為輕度狹窄37例。冠狀動脈病變狹窄直徑在71%-89%之間的為中都狹窄36例。冠狀動脈病變狹窄直徑為≥90%為重度狹窄49例。比較各組與對照組間及各組之間上述心肌酶標(biāo)記物及H-FABP濃度是否存在差異。計量資料采用均數(shù)±標(biāo)準(zhǔn)差(標(biāo)準(zhǔn)誤),并完成正態(tài)性及方差齊性檢驗,方差齊采用獨立樣本t檢驗行組間比較,方差不齊采用獨立樣本t’檢驗行組間比較,計數(shù)資料用卡方檢驗,檢驗標(biāo)準(zhǔn)a=0.05,P0.05為有統(tǒng)計學(xué)意義。結(jié)果：(1)單支病變組、雙支病變組及多支病變組CK、CK-MB、TnT、H-FABP濃度顯著高于對照組,差異有統(tǒng)計學(xué)意義(P0.05)。(2)雙支病變組、多支病變組檢測H-FABP濃度均顯著高于單支病變組,差異有統(tǒng)計學(xué)意義(P0.05)。(3)輕度狹窄組、中度狹窄組及重度狹窄組CK、CK-MB、TnT、H-FABP濃度顯著高于對照組,差異有統(tǒng)計學(xué)意義(P0.05)。(4)中度狹窄組、重度狹窄組檢測H-FABP濃度均顯著高于輕度狹窄組,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論：急性心肌梗死早期血清H-FABP濃度越高提示冠脈病變程度越重。
[Abstract]:Objective: to investigate the clinical significance and value of serum cardiac fatty acid binding protein H-FABPin in the early assessment of coronary artery disease in patients with acute myocardial infarction. Methods: from December 2012 to December 2013, we selected to visit Xinjiang Medical University from December 2012 to December 2013. 122 patients with acute myocardial infarction in the emergency department of the first affiliated Hospital were selected as the case group. At the same time, 50 patients in the same period of time were selected as the control group. The serum levels of CKCK-MBN TnT were measured. At the same time, the serum concentration of cardiac fatty acid binding protein was detected by ReLIA multifunctional immunoassay. The relationship between the above indexes and the severity of coronary artery lesion was analyzed. The coronal classification was based on the results of coronary arteriography. There were 47 patients with one vessel, 44 patients with 2 branches, 31 patients with more than 2 vessels. 37 patients with coronary artery stenosis between 50% and 70% had slight stenosis. The diameter of coronary artery stenosis ranged from 71% to 89%. There were 36 cases of moderate stenosis and 49 cases of severe stenosis with stenosis diameter 鈮，

本文編號：1543027