Our previous study demonstrated that BM-cyclin 1,a traditional anti-mycoplasma drug,could effectively reverse the multidrug resistance（MDR） of C-A120 cells.The present study aims to explore the reversal effect of BM-cyclin 1 on MDR and its mechanisms in BALB/C nude mice bearing C-A120 cells.Immunoblotting analysis and reverse transcription-polymerase chain reaction（RT-PCR） were used to study the change in multidrug resistance-associated protein 2（MRP2） induced by BM-cyclin 1.We found that the ex... 

【文章來源】：Journal of Huazhong University of Science and Technology（Medical Sciences）. 2013,33(06)

【文章頁數(shù)】：5 頁

【文章目錄】：
1 MATERIALS AND METHODS
    1.1 Chemicals and Reagents
    1.2 Cell Lines and Culture
    1.3 Tumorigenicity Experiments and Treatment of Established Tumors
    1.4 RT-PCR
    1.5 Chemical Colorimetry for GSH
    1.6 Immunoblot analysis
    1.7 Statistical Analysis
2 RESULTS
    2.1 Expression Level of MRP2 in C-A120 Cells
    2.2 Effect of BM-cyclin 1 on GSH Level in C-A120Cells
    2.3 Effect of BM-cyclin 1 on Growth of C-A120 Cells Xenografted in Nude Mice
    2.4 Expression Level of MRP2 in Nude Mice
3 DISCUSSION
Conflict of Interest Statement



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