本文選題：Beagle犬 + 雜種犬�。� 參考：《中國中藥雜志》2013年12期

【摘要】：目的:比較Beagle犬和雜種犬制作的急性心肌梗死模型,以及Beagle犬制備的心梗模型對藥物干預(yù)是否敏感。方法:采用麻醉犬冠狀動脈前降支結(jié)扎制備心肌梗死模型,觀察心臟的形態(tài)學(xué)變化,測定犬冠狀動脈前降支暴露的動脈長度及心臟系數(shù);描記心外膜電圖(∑ST,N-ST),計算心肌缺血程度;硝基四氮唑藍(N-BT)組織化學(xué)染色方法測定心肌梗死面積。結(jié)果:Beagle犬在∑ST,N-ST和心梗面積指標上與雜種犬比較均無顯著性差異;Beagle犬合心爽組的心梗面積顯著降低(P0.05,P0.01),∑ST和N-ST指標有明顯的降低趨勢,但與Beagle犬模型組比較無統(tǒng)計學(xué)差異。Beagle犬冠脈分支清晰規(guī)則,暴露的動脈長度較長,便于制備心肌梗死模型且臟器系數(shù)差異較小,雜種犬冠脈分支排列不規(guī)則,暴露的動脈長短不一,個體差異較大。結(jié)論:Beagle犬較雜種犬在心梗模型的制備上有一定的優(yōu)勢,且心梗模型對藥物干預(yù)敏感。
[Abstract]:Aim: to compare the acute myocardial infarction model between Beagle dog and hybrid dog and whether the myocardial infarction model made by Beagle dog is sensitive to drug intervention. Methods: myocardial infarction model was established by ligation of anterior descending branch of coronary artery in anesthetized dogs. Morphological changes of heart were observed and arterial length and heart coefficient of anterior descending branch of coronary artery were measured. Epicardial electrocardiogram (鈭，

本文編號：2057114