本文關(guān)鍵詞： 調(diào)節(jié)性T細(xì)胞 慢性淋巴細(xì)胞性白血病 Foxp 預(yù)后分析　出處：《細(xì)胞與分子免疫學(xué)雜志》2013年12期 　論文類型：期刊論文

【摘要】：目的探討慢性淋巴細(xì)胞性白血病(CLL)患者外周血中調(diào)節(jié)性T細(xì)胞(Treg)表達(dá)及其與預(yù)后的相關(guān)性。方法采用流式細(xì)胞術(shù)檢測(cè)30例健康體檢者和28例初診的CLL患者治療前后外周血的CD4+CD25+Treg、CD4+CD25+Foxp3+Treg數(shù)量,并對(duì)19例患者進(jìn)行了治療隨訪。結(jié)果初診CLL患者CD4+CD25+Treg高于健康對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);初診CLL患者CD4+CD25+Foxp3+Treg分別高于治療后組和健康對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05),治療后CD4+CD25+Foxp3+Treg高于健康對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。初診CLL患者CD4+CD25+Foxp3+Treg與CD38表達(dá)率、β2微球蛋白表達(dá)量、Zeta相關(guān)蛋白70(ZAP-70)陽(yáng)性表達(dá)、臨床Binet分期和Rai分期均呈正相關(guān)。結(jié)論 CD4+CD25+Foxp3+Treg有可能作為評(píng)估CLL患者疾病進(jìn)展、療效及預(yù)后的指標(biāo)之一。
[Abstract]:Objective to investigate the expression of regulatory T cell tregs in peripheral blood of patients with chronic lymphoblastic leukemia (CLL) and its correlation with prognosis. Methods flow cytometry was used to detect 30 healthy controls and 28 newly diagnosed CLL patients before treatment. The number of CD4 CD25 Foxp3 Treg in peripheral blood of CD4 CD25 Tregmonium was determined. Results the CD4 CD25 Treg in the newly diagnosed CLL patients was higher than that in the healthy control group (P 0.05), the CD4 CD25 Foxp3 Treg in the newly diagnosed CLL patients was higher than that in the post-treatment group and the healthy control group. After treatment, the CD4 CD25 Foxp3 Treg was significantly higher than that in the healthy control group (P 0.05). The expression rate of CD4 CD25 Foxp3 Treg and CD38 and the expression of 尾 2 microglobulin in the newly diagnosed CLL patients were significantly higher than those in the healthy control group (P 0.05), and the expression of 尾 2 microglobulin and Zeta associated protein 70 (ZAP-70) were positive. Conclusion CD4 CD25 Foxp3 Treg may be one of the indexes to evaluate the disease progression, curative effect and prognosis of CLL patients.
【作者單位】： 新疆醫(yī)科大學(xué)第一附屬醫(yī)院血液科;
【基金】：新疆維吾爾自治區(qū)自然科學(xué)基金(2013211A100)
【分類號(hào)】：R392.11

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