【摘要】：目的：探討多層螺旋CT（Multislice spiral computerized tomography，MSCT）肺容積測定與肺功能測定（Pulmonary function test，PFT）在慢性阻塞性肺氣腫早期數(shù)據(jù)相關(guān)性，評估二者在慢性阻塞性肺氣腫早期的診斷價值。 方法：臨床搜集具有明確吸煙病史并慢性支氣管炎患者67例，根據(jù)目前臨床診斷慢性阻塞性肺氣腫主要依據(jù)PFT測定指標(biāo)殘總比值（RV/TLC）大于40%即肺氣腫組31例，小于40%者為不能通過PFT測定診斷慢性阻塞性肺氣腫組36例，每一位患者于PFT測定結(jié)束3天內(nèi)行MSCT肺容積測定。采用SPSS17.0統(tǒng)計學(xué)軟件進(jìn)行數(shù)據(jù)處理，計量資料用（x s）表示，組間數(shù)據(jù)比較采用獨(dú)立樣本t檢驗，MSCT肺容積指標(biāo)深呼氣末容積（Vex）、深吸氣末容積（Vin）、深吸氣末與深呼氣末容積差值（Vin-Vex）、深呼氣末容積與深吸氣末比值（Vex/Vin）分別與PFT測定指標(biāo)殘氣量（RV）、肺總量（TLC）、用力肺活量（FVC）、殘總比值（RV/TLC）應(yīng)用相關(guān)性分析；MSCT肺容積指標(biāo)Vex/Vin與PFT測定指標(biāo)RV/TLC按RV/TLC大于40%為肺氣腫診斷標(biāo)準(zhǔn)，繪制ROC曲線評估其診斷價值。 結(jié)果：兩組數(shù)據(jù)比較其差異具有統(tǒng)計學(xué)意義（P＜0.05），MSCT肺容積指標(biāo)Vex與PFT測定指標(biāo)RV存在顯著相關(guān)性（r=0.927），Vin與TLC存在顯著相關(guān)性（r=0.831），Vex/Vin與RV/TLC存在中等程度相關(guān)性（r=0.664），ROC曲線顯示PFT測定指標(biāo)RV/TLC線下面積為0.712，MSCT肺容積指標(biāo)Vex/Vin線下面積為0.826，診斷慢性阻塞性肺氣腫早期優(yōu)于PFT測定指標(biāo)RV/TLC。 結(jié)論：MSCT肺容積測定指標(biāo)與PFT測定指標(biāo)具有相關(guān)性能夠反應(yīng)肺功能變化，MSCT肺容積指標(biāo)Vex/Vin較PFT測定指標(biāo)RV/TLC在反應(yīng)慢性阻塞性肺氣腫早期肺功能變化具有更高的準(zhǔn)確性，因此對診斷慢性阻塞性肺氣腫早期具有臨床預(yù)測意義，是較為敏感的指標(biāo)。目前臨床上缺乏MSCT相關(guān)診斷標(biāo)準(zhǔn)，因此有必要更為深入研究并制定更適合MSCT肺容積慢性阻塞性肺氣腫早期診斷標(biāo)準(zhǔn)，以利于更及時準(zhǔn)確發(fā)現(xiàn)和診斷慢性阻塞性肺氣腫早期患者。
[Abstract]:Objective: to investigate the correlation between multi-slice spiral CT (Multislice spiral computerized tomography,MSCT (lung volume measurement) and pulmonary function measurement (Pulmonary function test,PFT) in the early stage of chronic obstructive emphysema (COPD), and to evaluate their diagnostic value in the early stage of chronic obstructive emphysema (COPD). Methods: 67 patients with a definite history of smoking and chronic bronchitis were collected. According to the current clinical diagnosis of chronic obstructive emphysema, the residual total ratio (RV/TLC) measured by PFT was more than 40%, that is, 31 patients in emphysema group. Thirty-six patients with chronic obstructive emphysema (COPD) could not be diagnosed by PFT assay. MSCT pulmonary volume was measured within 3 days after PFT test in each of the 36 patients with chronic obstructive emphysema (COPD). SPSS17.0 statistical software was used to process the data, (x s) was used to express the measurement data, and independent sample t test was used to compare the data between groups. MSCT lung volume index, deep end expiratory volume (Vex), deep inspiratory end volume (Vin), were used to compare the data between groups. The difference between deep end-inspiratory volume and deep end-breath volume (Vin-Vex), the ratio of deep end-inspiratory volume to deep end-inspiratory volume (Vex/Vin) and PFT were measured by PFT, respectively. The total lung volume of (RV), was determined by (TLC), forced vital capacity (FVC),). The residual total ratio (RV/TLC) was analyzed by correlation analysis. According to the diagnostic criteria of emphysema, MSCT pulmonary volume index (Vex/Vin) and PFT index (RV/TLC) were measured according to RV/TLC > 40%. ROC curve was drawn to evaluate the diagnostic value of emphysema. Results: there was significant difference between the two groups (P < 0.05). There was a significant correlation between the lung volume index Vex and the PFT index RV (r 鈮，

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