【摘要】：目的探討并發(fā)新生兒呼吸窘迫綜合癥(RDS)的極低出生體重兒下呼吸道分泌物解脲脲原體(UU)感染與支氣管肺發(fā)育不良(BPD)的關(guān)系。方法選取73例診斷為RDS、早期使用機械通氣治療且至少應(yīng)用1劑肺表面活性物質(zhì)的極低出生體重兒,采用熒光定量聚合酶鏈反應(yīng)法檢測氣管內(nèi)吸出物UU核酸,分為UU感染組(n=21)和非感染組(n=52),比較兩組臨床特點及BPD的發(fā)生率。結(jié)果 UU感染組陰道產(chǎn)百分率及反復(fù)院內(nèi)肺部感染、胎膜早破發(fā)生率均高于非感染組;胎膜早破持續(xù)時間長于非UU感染組;且吸氧時間及住院時間均長于非UU感染組。UU感染組生后3 h內(nèi)血漿免疫球蛋白IgM、白細(xì)胞計數(shù)、中性粒細(xì)胞絕對值顯著高于非UU感染組。73例患兒中,發(fā)生BPD 45例,其中UU感染組BPD發(fā)生率(90%,19/21)顯著高于非UU感染組(50%,26/52),差異有統(tǒng)計學(xué)意義(P0.01)。結(jié)論下呼吸道UU感染可增加RDS極低出生體重兒BPD的發(fā)生率。
[Abstract]:Objective to investigate the relationship between Ureaplasma Urealyticum (UU) infection and bronchopulmonary dysplasia (BPD) in lower respiratory tract secretion of very low birth weight infants complicated with neonatal respiratory distress syndrome (RDS). Methods 73 cases of very low birth weight infants diagnosed as RDS, who were treated with mechanical ventilation and at least one dose of pulmonary surfactant were detected by fluorescence quantitative polymerase chain reaction (FQ-PCR). The patients were divided into two groups: UU infection group (nm21) and non-infected group (nnm52). The clinical characteristics and the incidence of BPD were compared between the two groups. Results the rate of vaginal birth and recurrent nosocomial pulmonary infection in UU infection group was higher than that in non-infection group, and the duration of premature rupture of membranes was longer in UU infection group than that in non UU infection group. The oxygen inhalation time and hospitalization time were longer than those in the non UU infection group. The plasma immunoglobulin IgM, leukocyte count in the UU infection group was significantly longer than that in the non UU infection group. The absolute value of neutrophil was significantly higher than that in the non UU infection group. 45 cases had BPD. The incidence of BPD in UU infection group (90 / 21) was significantly higher than that in non-UU infection group (50 / 52) (P0.01). Conclusion Lower respiratory tract UU infection can increase the incidence of BPD in RDS very low birth weight infants.
【作者單位】： 廣東省深圳市寶安區(qū)婦幼保健院新生兒科;
【分類號】：R563.8

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