幽門(mén)螺桿菌感染與慢性阻塞性肺疾病的相關(guān)性
發(fā)布時(shí)間：2018-08-07 17:25
【摘要】：目的分析幽門(mén)螺桿菌(Hp)感染與慢性阻塞性肺疾病(COPD)的相關(guān)性,并探討Hp感染對(duì)COPD患者肺功能的影響及血?dú)夥治龅那闆r。方法 (1)回顧性分析住院的305例COPD患者為研究組,另選取305例健康體檢者為對(duì)照組,將兩組對(duì)象進(jìn)行14C尿素呼氣試驗(yàn),比較兩組Hp陽(yáng)性率;(2)從305例COPD患者抽取140例Hp陽(yáng)性和140例Hp陰性的COPD患者,比較兩組的肺功能和血?dú)夥治龅那闆r。結(jié)果 (1)研究組的Hp陽(yáng)性率為66.8%,對(duì)照組為47.3%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P0.01)。(2)肺功能檢測(cè)結(jié)果示Hp陽(yáng)性的COPD患者的FEV_1/FVC和FEV_1%pre水平高于陰性組;血?dú)夥治鼋Y(jié)果顯示Hp陽(yáng)性COPD組的PaO_2和SaO_2水平低于陰性的COPD患者,而PaCO_2的水平高于Hp陰性的COPD患者(均P0.01)。結(jié)論 COPD患者感染率比健康人群高,Hp感染與COPD關(guān)系密切,可能是COPD患者肺功能惡化的重要致病因素。
[Abstract]:Objective to analyze the relationship between Helicobacter pylori (Hp) infection and chronic obstructive pulmonary disease (COPD), and to explore the effect of HP infection on pulmonary function and blood gas analysis in COPD patients. Methods (1) A retrospective analysis of 305 COPD patients as study group and 305 healthy persons as control group was performed. The 14C urea breath test was performed in both groups. (2) 140 cases of HP positive and 140 cases of HP negative COPD were collected from 305 patients with COPD, and the pulmonary function and blood gas analysis were compared between the two groups. Results (1) the positive rate of HP was 66.8 in the study group and 47.3 in the control group. There was a statistically significant difference between the two groups (P0.01). (2). The results of pulmonary function test showed that the FEV_1/FVC and FEV_1%pre levels of the patients with HP positive COPD were higher than those of the negative group. Blood gas analysis showed that the levels of PaO_2 and SaO_2 in HP positive COPD group were lower than those in HP negative COPD group, while PaCO_2 level was higher in HP negative COPD group than in HP negative COPD group (all P0.01). Conclusion the infection rate of HP in patients with COPD is higher than that in healthy people. HP infection is closely related to COPD and may be an important pathogenic factor for the deterioration of pulmonary function in patients with COPD.
【作者單位】： 廣東省潮州市人民醫(yī)院呼吸內(nèi)科;
【分類(lèi)號(hào)】：R563.9
[Abstract]:Objective to analyze the relationship between Helicobacter pylori (Hp) infection and chronic obstructive pulmonary disease (COPD), and to explore the effect of HP infection on pulmonary function and blood gas analysis in COPD patients. Methods (1) A retrospective analysis of 305 COPD patients as study group and 305 healthy persons as control group was performed. The 14C urea breath test was performed in both groups. (2) 140 cases of HP positive and 140 cases of HP negative COPD were collected from 305 patients with COPD, and the pulmonary function and blood gas analysis were compared between the two groups. Results (1) the positive rate of HP was 66.8 in the study group and 47.3 in the control group. There was a statistically significant difference between the two groups (P0.01). (2). The results of pulmonary function test showed that the FEV_1/FVC and FEV_1%pre levels of the patients with HP positive COPD were higher than those of the negative group. Blood gas analysis showed that the levels of PaO_2 and SaO_2 in HP positive COPD group were lower than those in HP negative COPD group, while PaCO_2 level was higher in HP negative COPD group than in HP negative COPD group (all P0.01). Conclusion the infection rate of HP in patients with COPD is higher than that in healthy people. HP infection is closely related to COPD and may be an important pathogenic factor for the deterioration of pulmonary function in patients with COPD.
【作者單位】： 廣東省潮州市人民醫(yī)院呼吸內(nèi)科;
【分類(lèi)號(hào)】：R563.9
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