本文選題：肺炎支原體感染 + 哮喘發(fā)作��； 參考：《中華醫(yī)院感染學(xué)雜志》2017年21期

【摘要】：目的分析脾氨肽凍干粉口服治療肺炎支原體(MP)感染所致哮喘發(fā)作患者的臨床療效,為MP感染哮喘發(fā)作患者臨床治療提供參考。方法選擇2015年3月-2016年3月醫(yī)院治療的MP感染致哮喘發(fā)作患者108例,采用隨機(jī)數(shù)字表法將患者分為對照組和試驗(yàn)組,每組54例,對照組患者采用常規(guī)對癥治療及抗菌藥物治療,試驗(yàn)組患者在對照組治療方案基礎(chǔ)上,加用脾氨肽凍干粉口服治療,兩組患者均連續(xù)治療2周,比較兩組患者入組、治療后免疫球蛋白IgG、IgA、IgM、T淋巴細(xì)胞亞群CD3+、CD_4~+、CD_8~+ 、CD_4~+/CD_8~+ 變化情況,并評價兩組患者的臨床癥狀評分。結(jié)果治療2周后,兩組患者IgG、IgA較治療前均升高,IgM較治療前降低(P0.05),但試驗(yàn)組患者治療后IgG、IgA高于對照組患者,IgM低于對照組患者(P0.05);兩組患者治療后CD3+、CD_4~+、CD_4~+/CD_8~+ 較治療前升高(P0.05),CD_8~+ 較治療前明顯降低(P0.05),但試驗(yàn)組患者治療后CD3+、CD_4~+、CD_4~+/CD_8~+ 高于對照組患者(P0.05),CD_8~+ 低于對照組患者(P0.05);兩組患者治療后哮喘臨床癥狀評分均較治療前有明顯降低,但治療后試驗(yàn)組哮喘臨床癥狀評分明顯低于對照組(P0.05)。結(jié)論脾氨肽凍干粉口服輔助治療可有效降低MP感染致哮喘發(fā)作患者哮喘臨床癥狀評分,改善患者T淋巴細(xì)胞亞群構(gòu)成,提高患者免疫功能,對MP感染致哮喘患者的治療具有較高的臨床價值。
[Abstract]:Objective to analyze the clinical efficacy of spleen aminopeptide lyophilized powder in the treatment of asthma attack caused by MP infection, and to provide reference for the clinical treatment of MP infected asthma attack patients. Methods from March 2015 to March 2016, 108 patients with asthma caused by MP infection were divided into control group (n = 54) and experimental group (n = 54). The patients in control group were treated with routine symptomatic therapy and antimicrobial therapy. The patients in the experimental group were treated with spleen aminopeptide lyophilized powder orally on the basis of the treatment plan of the control group. The patients in both groups were treated continuously for 2 weeks. After treatment, the immunoglobulin IgG / IgA T lymphocyte subsets (CD3 / CD4 / CD8 / CD8 ~ +) were collected and the clinical symptom scores of the two groups were evaluated. Results after 2 weeks of treatment, The IgG IgA of both groups was higher than that before treatment, but the IgGG IgA of the patients in the trial group was higher than that of the control group after treatment, and that of the patients in the two groups was lower than that of the control group (P 0.05). After treatment, the levels of CD3 CD4 ~ / CD8 ~ in the patients of the two groups were higher than those before the treatment. After treatment, the patients in the trial group were significantly lower than those in the control group in terms of CD3 / CD4 / CD8- / CD8, and the clinical symptom scores of the two groups were significantly lower than those of the control group, and the clinical symptoms of the patients in the two groups were significantly lower than those in the control group. After treatment, the clinical symptom score of asthma in the trial group was significantly lower than that in the control group (P 0.05). Conclusion the oral adjuvant therapy of spleen aminopeptide lyophilized powder can effectively reduce the clinical symptom score of asthma patients with MP infection, improve the T lymphocyte subsets, and improve the immune function of the patients. The treatment of MP infection induced asthma has high clinical value.
【作者單位】： 鄭州大學(xué)附屬洛陽中心醫(yī)院呼吸內(nèi)科;
【分類號】：R562.25

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 強(qiáng)立;以持續(xù)高熱為臨床表現(xiàn)的肺炎支原體感染34例分析[J];江蘇醫(yī)藥;2001年03期

2 朱明哲,姜宏杰,尹華英;淺談肺炎支原體感染[J];新醫(yī)學(xué);2002年02期

3 楊繼芳,楊玉明,張志華;肺炎支原體感染并發(fā)傳染性單核細(xì)胞增多癥1例[J];河北醫(yī)學(xué);2003年02期

4 李春元;;肺炎支原體感染[J];國外醫(yī)學(xué)(流行病學(xué)傳染病學(xué)分冊);1991年03期

5 孫書明,王飆貴,余素明;肺炎支原體感染臨床X線表現(xiàn)(附114例報告)[J];北京醫(yī)學(xué);1999年03期

6 陳英男,李艷玲,石偉琢;肺炎支原體感染41例臨床分析[J];齊齊哈爾醫(yī)學(xué)院學(xué)報;2000年06期

7 歐陽菊艷,甘露;成人肺炎支原體感染31例臨床分析[J];中國冶金工業(yè)醫(yī)學(xué)雜志;2000年04期

8 陸宇飛,田毅,丁曉燕,趙洪茹;41例成人肺炎支原體感染臨床分析[J];中國實(shí)驗(yàn)診斷學(xué);2000年02期

9 歐陽菊艷,常蓮芳;成人肺炎支原體感染115例臨床分析[J];新疆醫(yī)科大學(xué)學(xué)報;2001年02期

10 耿建梅,刁士燕;國內(nèi)肺炎支原體感染特點(diǎn)及其處理方法研究進(jìn)展[J];華北煤炭醫(yī)學(xué)院學(xué)報;2002年02期

相關(guān)會議論文 前2條

1 李國華;劉文娟;鮑玉新;張淑萍;;成人肺炎支原體感染兩種檢測方法的對比研究及分析[A];中華醫(yī)學(xué)會呼吸病學(xué)年會——2013第十四次全國呼吸病學(xué)學(xué)術(shù)會議論文匯編[C];2013年

2 劉春靈;田庚善;周平;王純巍;王占勇;孫紹權(quán);周艷;孫瑩;孫妍;張宏偉;李莉;;與醫(yī)院病房相關(guān)的一起肺炎支原體感染家庭爆發(fā)的調(diào)查[A];中華醫(yī)學(xué)會呼吸病學(xué)年會——2011（第十二次全國呼吸病學(xué)學(xué)術(shù)會議）論文匯編[C];2011年

相關(guān)碩士學(xué)位論文 前2條

1 高偉;肺炎支原體感染的臨床治療分析及免疫學(xué)致病機(jī)制研究[D];天津醫(yī)科大學(xué);2011年

2 周阿旺;支氣管哮喘氣道炎癥和哮喘控制與肺炎支原體感染的相關(guān)性研究[D];浙江大學(xué);2015年

，

本文編號：1926079