發(fā)布時(shí)間：2018-05-03 01:20

  本文選題：醫(yī)源性感染 + 耐碳青霉烯類銅綠假單胞菌��； 參考：《中華醫(yī)院感染學(xué)雜志》2017年11期

【摘要】：目的探討耐碳青霉烯類銅綠假單胞菌(CRPA)及耐碳青霉烯類鮑氏不動(dòng)桿菌(CRAB)的耐藥機(jī)制,為指導(dǎo)臨床合理選擇抗菌藥物提供治療依據(jù)。方法回顧性調(diào)查2014年1月-2015年12月醫(yī)院肺部感染住院患者送檢的各類標(biāo)本中檢出病原菌577株,采用改良Hodge方法測(cè)定碳青霉烯酶表型,采用B-last方法測(cè)定超廣譜β-內(nèi)酰胺酶,分析CRPA及CRAB的耐藥性及檢出率的相關(guān)性。結(jié)果銅綠假單胞菌對(duì)亞胺培南、美羅培南的耐藥率為32.95%和29.55%,而對(duì)阿米卡星的耐藥率為5.11%,對(duì)磺胺甲惡唑/甲氧芐啶100.00%耐藥;鮑氏不動(dòng)桿菌對(duì)亞胺培南和美羅培南的耐藥率均為47.75%,而對(duì)氨曲南100.00%耐藥;176株P(guān)AE檢出CRPA 31株,檢出率17.61%,檢出耐亞胺培南PAE 17株,檢出率54.84%,檢出耐美羅培南PAE 14株,檢出率45.16%;178株ABA檢出CRAB 39株,檢出率21.91%,檢出耐亞胺培南ABA 22株,檢出率56.41%,檢出耐美羅培南ABA 17株,檢出率43.59%。結(jié)論醫(yī)源性感染患者CRPA及CRAB的耐藥率呈逐年增加,臨床醫(yī)師應(yīng)根據(jù)細(xì)菌鑒定和藥敏結(jié)果正確合理使用抗菌藥物,以便提高療效和減少耐藥菌株的發(fā)生。
[Abstract]:Objective to explore the drug resistance mechanism of carbapenem-resistant Pseudomonas aeruginosa (CRPA) and carbapenem-resistant Acinetobacter baumannii (CRA) and to provide therapeutic basis for clinical rational selection of antimicrobial agents. Methods from January 2014 to December 2015, 577 strains of pathogenic bacteria were detected from hospitalized patients with pulmonary infection. The phenotypes of carbapenem were determined by modified Hodge method, and extended spectrum 尾 -lactamases were determined by B-last method. To analyze the correlation between drug resistance and detection rate of CRPA and CRAB. Results the resistance rates of Pseudomonas aeruginosa to imipenem and meropenem were 32.95% and 29.55%, while those to amikacin were 5.11% and 100.00% to sulfamethoxazole / trimethoprim. The resistant rates of Acinetobacter baumannii to imipenem and meropenem were 47.75, while to amtreonam 100.00%, CRPA 31 strains were detected in PAE, the detectable rate was 17.61%, 17 strains of imipenem resistant PAE were detected, the detection rate was 54.84%, and 14 strains of meropenem PAE were detected. 39 strains of CRAB were detected in 45.16 strains of ABA, 21.91 strains were detected, 22 strains of imipenem resistant ABA were detected, the detectable rate was 56.41%, and 17 strains of meropenem ABA were detected, the detection rate was 43.59%. Conclusion the drug resistance rates of CRPA and CRAB in iatrogenic infection patients are increasing year by year. The clinicians should use antibiotics correctly and reasonably according to the results of bacterial identification and drug sensitivity in order to improve the efficacy and reduce the occurrence of drug-resistant strains.
【作者單位】： 河南科技大學(xué)臨床醫(yī)學(xué)院河南科技大學(xué)第一附屬醫(yī)院藥劑科;青島大學(xué)醫(yī)院藥劑科;青島大學(xué)附屬醫(yī)院檢驗(yàn)科;河南大學(xué)淮河醫(yī)院神經(jīng)內(nèi)科;
【基金】：河南科技攻關(guān)基金資助項(xiàng)目(112102310090)
【分類號(hào)】：R563.1

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 王昌明;王晨;俞蓮花;王冬國(guó);;鮑氏不動(dòng)桿菌致呼吸機(jī)相關(guān)性肺炎的臨床分析[J];中華醫(yī)院感染學(xué)雜志;2008年05期

2 方群;黃興友;毛向紅;趙惠芬;;鮑氏不動(dòng)桿菌致呼吸機(jī)相關(guān)性肺炎原因分析及干預(yù)對(duì)策[J];中華醫(yī)院感染學(xué)雜志;2008年10期

3 丁志平;邢玉斌;徐雅萍;董U，

本文編號(hào)：1836346