本文選題：肺氣腫 + 甲基波尼松龍��； 參考：《重慶醫(yī)學(xué)》2017年09期

【摘要】：目的探討吸煙誘導(dǎo)肺氣腫大鼠血清抗血管內(nèi)皮細(xì)胞抗體(AECA)的表達(dá),分析甲基波尼松龍對其干預(yù)影響。方法將39只大鼠隨機分為對照組、吸煙大鼠肺氣腫模型組(模型組)、甲基波尼松龍干預(yù)組(干預(yù)組)。模型組及干預(yù)組進(jìn)行煙霧暴露被動吸煙1個月時,對干預(yù)組腹腔注射甲基波尼松龍(每天1次,每周6d)。煙霧暴露90d后,比較各組大鼠血清AECA、支氣管肺泡灌洗液(BACF)中白細(xì)胞介素-8(IL-8)、基質(zhì)金屬蛋白酶-9(MMP-9)、腫瘤壞死因子-α(TNF-α)及肺組織中肺平均內(nèi)襯間隔(MLI)、平均肺泡數(shù)(MAN)的差異。結(jié)果模型組血清AECA比對照組、干預(yù)組升高(P0.05);模型組BALF中IL-8、TNF-α、MMP-9水平較對照組、干預(yù)組均升高(P0.05)。結(jié)論 AECA參與吸煙誘導(dǎo)肺氣腫大鼠形成,甲基波尼松龍可降低AECA及細(xì)胞炎癥因子水平,并影響肺氣腫的形成。
[Abstract]:Objective to investigate the expression of anti vascular endothelial cell antibody (AECA) in the serum of rats with emphysema induced by smoking and to analyze the effect of methyl Bonisone on it.Methods Thirty-nine rats were randomly divided into control group, emphysema model group (model group) and methylBonisone intervention group (intervention group).When the model group and the intervention group were exposed to smoke for 1 month, the intervention group was injected intraperitoneally with methylBonisone once a day, 6 days a week.After 90 days of smoke exposure, the differences of serum AECA, BACFC in bronchoalveolar lavage fluid (BACFF), interleukin-8 (IL-8), matrix metalloproteinase-9 (MMP-9), tumor necrosis factor- 偽 (TNF- 偽), and the mean pulmonary lining interval (MLI) and the number of alveoli (MAN) in lung tissue were compared.Results compared with the control group, the serum AECA in the model group was higher than that in the control group, and the level of IL-8 TNF- 偽 -MMP-9 in the BALF of the model group was higher than that in the control group, and that in the intervention group was higher than that in the control group.Conclusion AECA is involved in the formation of emphysema induced by smoking. MethylBonisone can decrease the levels of AECA and cytokines and affect the formation of emphysema.
【作者單位】： 貴州省人民醫(yī)院呼吸與危重癥醫(yī)學(xué)科;
【基金】：國家自然科學(xué)基金資助項目(81060006) 十二五國家科技支撐計劃課題資助項目(2013bai09b09) 貴州省科學(xué)技術(shù)基金資助項目[黔科合j字(2011)2251]
【分類號】：R563.3

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