三維斑點(diǎn)追蹤技術(shù)評(píng)價(jià)初發(fā)腎病綜合征患兒左心室整體應(yīng)變
[Abstract]:Objective: to investigate the characteristics of left ventricular strain in children with primary nephrotic syndrome (Initial onset of nephrotic syndrome,INS) by three-dimensional speckle tracing imaging (Three-dimensional speckle tracking imaging,3D-STI). The changes of the above indexes in children with different 24 h urinary protein contents were analyzed. Methods: 42 children with INS (case group) and 30 healthy children (control group) were examined by 3D-STI, and three dimensional left ventricular ejection fraction (Three-dimensional left ventricular ejection fraction,3D-LVEF) was obtained. Left ventricular global longitudinal peak strain (Left ventricular global longitudinal strain,LVGLS), left ventricular peak strain (Left ventricular global circumferential strain,LVGCS), left ventricular area peak strain (Left ventricular global area strain,LVGAS), left ventricular radial peak strain (Left ventricular global radial strain,) LVGRS), used normal test to select the appropriate statistical method to compare the above parameters between the two groups, and randomly selected 20 cases of INS children to carry out intra-group and inter-group reproducibility test, and draw scatter plot. Then the children with INS were divided into 3 groups according to the total amount of 24 h urine protein, and the differences of the above parameters in the three groups were compared. Results: 1 there was no significant change in LVEF in the case group compared with the control group (P0.05). Compared with the control group, the LVGAS and LVGLS in the 3D-STI group were significantly lower than those in the control group (P0.01), LVGRS and LVGCS, respectively). After Bland-Altman repeatability test, the average difference of LVGAS,LVGCS,LVGLS,LVGRS between groups was -0.2 ~ 0.13% and -2.8% ~ (-2.33) ~ (-1.65)% confidence intervals, respectively. -2.1% and -3.9% respectively; The average difference of LVGAS,LVGCS,LVGLS,LVGRS in the group was 0.0-0.36-0.4 and 0.1U 95% confidence intervals, respectively. The mean confidence intervals of LVGAS,LVGCS,LVGLS,LVGRS were -2.9 and 2.18, respectively. -3.2% and -4.4%. The strain values of INS patients within and between groups had good reproducibility. 3 the parameters of the three groups divided according to 24 h urine protein volume were compared. Only LVGAS and LVGLS had significant statistical differences among the three groups. The above strain value decreased with the increase of 24 h urine protein content. Conclusion: there are obvious abnormal changes in global strain of left ventricle in children with INS, and 3D-STI technique has good reproducibility in evaluating the strain of left ventricle. With the increase of 24 h urinary protein, the global strain of left ventricle may be related to the severity of the disease.
【作者單位】: 中國醫(yī)科大學(xué)附屬盛京醫(yī)院超聲科;
【基金】:遼寧省科技廳科學(xué)技術(shù)計(jì)劃項(xiàng)目(2013225049)
【分類號(hào)】:R726.9;R540.45
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