輕微肝性腦病大腦結(jié)構(gòu)與功能異常MRI表現(xiàn)
[Abstract]:Objective to observe the changes of gray matter structure and function in patients with mild hepatic encephalopathy (MHE) secondary to liver cirrhosis (HC). Methods 30 patients with HC (32 patients with), HC accompanied with MHE in HC group (MHE group) and 34 healthy controls (control group) underwent neuropsychological tests and structural and functional MR scans. The changes of brain gray matter structure and ReHo were analyzed based on morphologic and local consistent (ReHo) method of voxel. Results the time to complete NCT-A in MHE group was significantly higher than that in HC group and control group, while the DST score in MHE group was significantly lower (P 0.001). Compared with the control group, the area and intensity of gray matter volume change in MHE group were significantly increased. The (MFG) volume of caudate nucleus and orbital medial frontal gyrus decreased and thalamus enlarged only in MHE group. The decrease of ReHo in bilateral thalamus was found only in simple HC group. The decrease of (SFG) in medial superior frontal gyrus of (SMA), and (ACC) ReHo in anterior cingulate gyrus in bilateral auxiliary motor area was mainly found in MHE group. There was a positive correlation between the volume of thalamus and the mean ReHo in HC and MHE groups (r = 0.342P ~ (0.007). There was a positive correlation between the volume of thalamus and the volume of MFG in orbit (r = 0.448). The mean ReHo value of SMA,ACC and medial SFG was negatively correlated with the completion time of NCT-A (r = 0. 529 ~ 0. 414 ~ 0. 450) and positively correlated with the DST score (r = 0. 562P = 0. 483n, P = 0. 05). Conclusion the study of combined structure and function MRI may provide a more reliable objective basis for the diagnosis and pathogenesis of MHE. The changes of thalamus, caudate nucleus, frontal lobe and cingulate gyrus volume and ReHo may be the MRI imaging features of MHE brain structure and function injury.
【作者單位】: 白求恩國際和平醫(yī)院放射科;第三軍醫(yī)大學(xué)西南醫(yī)院放射科;第三軍醫(yī)大學(xué)西南醫(yī)院感染科;
【基金】:河北省自然科學(xué)基金(H2014505007)
【分類號(hào)】:R575.3;R445.2
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