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經(jīng)腫塊周圍皮下與經(jīng)腫塊周圍腺體內(nèi)注射超聲造影劑檢測乳腺癌前哨淋巴結(jié)的對比研究

發(fā)布時間:2018-10-29 12:52
【摘要】:目的探討超聲造影檢測乳腺癌前哨淋巴結(jié)(SLN)的最佳造影劑注射部位和其臨床價值。 方法對65例乳腺癌患者分別經(jīng)腫塊周圍皮下及腫塊周圍腺體內(nèi)注射超聲造影劑,觀察并記錄腋窩淋巴結(jié)造影增強(qiáng)情況。最終與亞甲藍(lán)染色及病理結(jié)果對照。 結(jié)果1.本研究65例乳腺癌患者中,經(jīng)腫塊周圍皮下注射超聲造影劑檢出SLN57例共79枚,檢出率為86.81%(79/91),經(jīng)腫塊周圍腺體內(nèi)注射SLN檢出率為58.24%(53/91),對比二者SLN檢出情況差異有統(tǒng)計學(xué)意義(P0.05); 2.經(jīng)腫塊周圍皮下注射超聲造影判定SLN轉(zhuǎn)移的準(zhǔn)確度為88.61%(70/79),敏感度為94.92%(56/59),特異度為70.00%(14/20);經(jīng)腫塊周圍腺體內(nèi)注射超聲造影檢測SLN的準(zhǔn)確度為86.79%(46/53),敏感為度82.50%(33/40),特異度為100%(13/13),二者判定SLN轉(zhuǎn)移與否的準(zhǔn)確度、敏感度和特異度之間差異無統(tǒng)計學(xué)意義(P0.05); 3.經(jīng)腫塊周圍皮下注射超聲造影劑SLN開始增強(qiáng)時間、達(dá)峰時間均較經(jīng)腺體內(nèi)注射時間短,且二者之間差異有統(tǒng)計學(xué)意義(P0.05)。 結(jié)論1.經(jīng)乳腺腫塊周圍皮下CEUS可以較為準(zhǔn)確地檢出SLN并判斷其是否轉(zhuǎn)移。 2.經(jīng)乳腺腫塊周圍皮下注射超聲造影劑后,SLN顯影速度快,且操作簡單、易于掌握,因而有較高的臨床實用價值。
[Abstract]:Objective to investigate the best contrast media injection site and its clinical value for detecting sentinel lymph node (SLN) in breast cancer by contrast-enhanced ultrasonography. Methods 65 patients with breast cancer were treated by subcutaneous and intraglandular injection of ultrasound contrast media respectively. The contrast enhancement of axillary lymph nodes was observed and recorded. The final results were compared with methylene blue staining and pathology. Result 1. In this study, 79 cases (86.81%) of SLN57 were detected by subcutaneous injection of ultrasound contrast agent around the tumor, and 58.24% (53 / 91) by intraglandular injection of SLN. There was significant difference in SLN detection between the two groups (P0.05). 2. The accuracy, sensitivity, specificity and specificity of SLN metastasis were 88.61% (70 / 79), 94.92% (56 / 59) and 70.00% (14 / 20), respectively. The accuracy, sensitivity and specificity of intraglandular injection echocardiography in detecting SLN were 86.79% (46 / 53), 82.50% (33 / 40) and 100% (13 / 13), respectively. There was no significant difference between sensitivity and specificity (P0.05). 3. The enhancement time of SLN was shorter than that of intraglandular injection, and the difference was statistically significant (P0.05). Conclusion 1. SLN can be detected accurately by subcutaneous CEUS around breast mass and whether it is metastasized or not. 2. After subcutaneous injection of ultrasound contrast agent into the surrounding breast masses, SLN has a high clinical value because of its rapid development, simple operation and easy control.
【學(xué)位授予單位】:寧夏醫(yī)科大學(xué)
【學(xué)位級別】:碩士
【學(xué)位授予年份】:2014
【分類號】:R445.1;R737.9

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