【摘要】：目的采用高頻超聲評估表阿霉素(Epi)復(fù)合藥物對乳腺癌患者血管內(nèi)皮功能的影響。方法收集140例乳腺癌術(shù)后患者,分為3組:A組為對照組,40例,未給予化療。B組50例,采用以Epi為主化療方案(環(huán)磷酰胺+Epi+5-氟尿嘧啶),Epi累積劑量180~240mg/m2;C組50例,化療方案與B組相同,Epi≥360mg/m2。對3組患者靜息狀態(tài)、反應(yīng)性充血(內(nèi)皮依賴性)及含服硝酸甘油后內(nèi)皮功能(內(nèi)皮非依賴性)進行檢測,比較內(nèi)皮依賴性及內(nèi)皮非依賴性肱動脈內(nèi)徑變化。結(jié)果 1A組與B組肱動脈內(nèi)皮依賴性舒張功能(EDD)的差異無統(tǒng)計學(xué)意義[(8.05±1.89)%vs(7.48±2.06)%,P0.05],C組EDD[(6.49±1.63)%]明顯減低,與A組、B組的差異均有統(tǒng)計學(xué)意義(P均0.05);2與A組[(14.81±4.20)%]比較,B組[(14.31±3.89)%]、C組內(nèi)皮非依賴性舒張功能[NEDD,(13.31±3.45)%]均減低,但3組間差異無統(tǒng)計學(xué)意義(P0.05);3EDD、NEDD與靜息狀態(tài)下肱動脈基礎(chǔ)內(nèi)徑(D0)無相關(guān)性(r=-0.02,0.01,P均0.05),EDD、NEDD與反應(yīng)性充血后肱動脈內(nèi)徑(D1)呈正相關(guān)(r=0.43,0.17,P0.05),與含服硝酸甘油后肱動脈內(nèi)徑(D2)呈正相關(guān)(r=0.23,0.69,P0.05)。結(jié)論較大劑量Epi復(fù)合藥物可致乳腺癌患者EDD功能受損,但其NEDD功能未見明顯受損。
[Abstract]:Objective to evaluate the effect of epirubicin (Epi) on vascular endothelial function in breast cancer patients by high frequency ultrasound. Methods one hundred and forty patients with breast cancer after operation were divided into 3 groups: control group (n = 40) and group B (n = 50). 50 patients in group C were treated with Epi regimen (cyclophosphamide Epi 5-fluorouracil). The chemotherapy regimen was the same as that in group B with Epi 鈮，

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