本文選題：磁共振成像 + 腦老化��； 參考：《河北醫(yī)科大學》2014年碩士論文

【摘要】：目的：通過VBM技術研究正常腦老化過程中白質體積發(fā)生年齡相關性改變的規(guī)律及性別差異性。 方法：自2013年8月-2013年11月招募健康成年志愿者，均行常規(guī)顱腦核磁共振成像（magnetic resonance imaging, MRI）和T1加權3D快速場回波（T1weighted image Fast Field Echo, T1-FFE）序列檢查。共選出187例符合納入標準的受檢者，其中男性92例，女性95例，年齡范圍20-78歲，平均年齡47.2歲，中位年齡47歲。將所有被試按性別和年齡分為青年組、中年組和老年組。采用基于體素的形態(tài)測量法(Voxel-basedmorphometry, VBM)，對腦結構圖像T1-FFE序列進行預處理，分割平滑后得到全腦白質體積數據進行統(tǒng)計分析。采用兩樣本t檢驗比較男女性別之間全腦白質體積有無差異。采用方差分析方法對不同性別、年齡組間白質體積的變化進行分析。采用回歸分析檢測所有研究對象全腦白質體積與年齡相關性進行分析。視P0.05的腦區(qū)為差異有統(tǒng)計學意義。同時采用回歸分析檢測各感興趣區(qū)白質體積與年齡的相關關系。 結果： 1全腦白質體積性別差異分析：調整顱內總體積后，，女性較男性具有更大的白質體積，差別具有統(tǒng)計學意義（t=3.79, P=0.0001, FDR校正）。局部白質體積在女性較大的腦區(qū)主要位于：延髓、腦橋、兩側大腦腳、兩側顳葉內側回、兩側小腦前葉、左側枕葉、兩側額上回、左側額葉眶回、兩側頂葉、扣帶回膝部。局部白質體積在男性較大的區(qū)域主要位于兩側小腦后葉、兩側島葉外囊、兩側額葉直回，以及在兩側頂葉和左側枕葉局部腦區(qū)。 2不同年齡組之間白質體積改變的分析：使用雙因素方差分析分別比較三組之間的腦白質體積差異，發(fā)現每兩組之間白質體積均存在顯著的年齡主效應(P0.05, FDR校正)。中年組與青年組比較，白質體積表現為增加的腦區(qū)位于兩側額葉直回、兩側中央前回、兩側放射冠、兩側內囊前肢、右側外囊、右側小腦中腳、兩側顳葉鉤回、兩側豆狀核、右側枕葉。老年組和青年組比較顯示局部白質體積減少的腦區(qū)主要位于兩側額葉、兩側大腦腳、兩側內囊后肢、左側內囊前肢、胼胝體壓部、兩側枕葉、左側顳葉、前扣帶回。老年組和中年組比較顯示局部白質體積萎縮的腦區(qū)主要位于兩側顳葉內側回、兩側顳下回、左側顳上回、兩側大腦腳、兩側丘腦、兩側額中回、左側額下回、兩側放射冠、胼胝體體部和膝部、兩側扣帶回、左側頂葉、兩側海馬旁回、右側楔前葉及兩側小腦部分腦區(qū)。另外，青年組和中年組比較時，若不采用多重對比校正(P0.001,未校正)，部分腦區(qū)表現為女性的相對保護，主要位于兩側小腦半球、腦橋前部、延髓、左側放射冠、左側枕葉等。同樣老年組和青年組比較時，若不采用多重對比校正(P0.001,未校正)可觀察到部分腦區(qū)，如兩側放射冠、兩側海馬、左側外囊、左側內囊后肢等，表現為女性對上述腦區(qū)的相對保護作用。青年組、中年組及中年組三組中各兩組之間均未發(fā)現顯著的年齡×性別交互效應(P0.05, FDR校正)。 3腦白質體積與年齡的相關性分析：全腦白質體積與年齡呈非線性、二次方式倒“U”型變化趨勢，R2=0.124, P＜0.000。將各感興趣區(qū)白質體積作為應變量進行回歸分析，結果顯示額葉為年齡相關性最強的腦區(qū)，R2=0.13，P0.001。而枕葉出現年齡相關性萎縮的時間最晚。兩側小腦半球、中腦、腦橋及延髓與年齡間未見顯著相關性。 結論： 1在調整顱內總體積的情況下，全腦白質體積分布存在性別的差異，在大部分腦區(qū)女性具有更大白質體積，并且在老化過程中，部分腦區(qū)（如兩側放射冠、兩側海馬旁回、左側枕葉、左側大腦腳及左側內囊等）女性表現為相對保護作用。 2在正常老化過程中，全腦白質體積與年齡呈現為二次方式、倒“U”型相關性改變，約在50歲達到最大值，之后逐漸減少。但是不同腦區(qū)一般以“后進先出”的規(guī)律呈現不同模式，額葉年齡相關性最強，枕葉受年齡影響時間較晚。 3兩側小腦半球、中腦、腦橋及延髓隨年齡并未表現出顯著相關性。
[Abstract]:Objective : To study the changes of age - related changes in white matter volume during normal brain aging by VBM technique .

Methods : Healthy adult volunteers were recruited from August 2013 to November 2013 . 187 cases were selected according to normal brain nuclear magnetic resonance imaging ( MRI ) and T1 weighted 3D fast field echo ( T1 - FFE ) sequence .

Results :

1 Whole brain white matter volume sex difference analysis : after adjusting the total volume of intracranial volume , the female had greater white matter volume than the male , and the difference had statistical significance ( t = 3.79 , P = 0.0001 ) . The local white matter volume is mainly located in the medulla , the brain bridge , the cerebral feet on both sides , the medial gyrus of the temporal lobe on both sides , the frontal lobe of the left frontal lobe , the left occipital lobe , the frontal gyrus of the left frontal lobe , the left frontal lobe , the parietal lobe on both sides , and the back knee .

2 . Analysis of the change of white matter volume between different age groups : A two - factor variance analysis was used to compare the difference of brain white matter volume between the three groups . It was found that there was a significant age - dominant effect between the two groups ( P0.05 ) . In the aged group and the middle - aged group , the brain areas with reduced local white matter volume were mainly located on the medial gyrus , the left parietal lobe , the left superior cerebellar peduncle , the left temporal lobe , the left occipital lobe , the right occipital lobe , the left temporal lobe and the left occipital lobe . The relative protective effects of female on the above - mentioned brain regions were observed in the left inner capsule hind limbs , etc . There were no significant differences in age and sex between the young group , middle - aged group and middle - aged group ( P0.05 ) .

The relationship between brain white matter volume and age was analyzed : the whole brain white matter volume and age were non - linear , the quadratic form inverted " U " type change trend , R2 = 0.124 , P < 0.000 . The white matter volume of each region of interest was analyzed by regression analysis . The results showed that the frontal lobe was the most age - related brain region , R2 = 0.13 , P0.001 .

Conclusion :

1 . In the case of adjusting the total intracranial volume , there is a gender difference in the whole brain white matter volume distribution , and in most brain regions , women have a greater white matter volume , and in the aging process , women in some brain regions ( such as bilateral radiation crowns , parahippocampal gyrus , left occipital lobe , left brain foot , left side inner capsule , etc . ) behave as a relative protection function .

2 . In the course of normal aging , the whole brain white matter volume and age were presented in the second way , the " U " type correlation was changed , the maximum was reached at the age of 50 years , and then decreased gradually . However , the different brain regions generally showed different patterns with the laws of " LIFO " , the correlation between frontal and leaf age was strongest , and the age of the occipital lobe was relatively late .

There was no significant correlation between the cerebellum hemisphere , midbrain , brain bridge and medulla with age on both sides .
【學位授予單位】：河北醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R338;R445.2

【引證文獻】

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1 杜威;磁共振波譜成像的NAA/Cr、Cho/Cr比值在中年人高血壓腦損傷的橫斷面研究[D];河北醫(yī)科大學;2016年

2 李丹;高血壓對中年人腦白質完整性影響的彌散張量成像研究[D];河北醫(yī)科大學;2016年

本文編號：2036544