本文選題：癲癇　切入點：磁共振成像　出處：《放射學(xué)實踐》2015年07期 　論文類型：期刊論文

【摘要】：目的:采用同步腦電圖聯(lián)合功能磁共振(EEG-fMRI)分析Rolandic癲癇(RE)患者腦區(qū)激活區(qū)域偏側(cè)性與腦電圖(EEG)偏側(cè)性的關(guān)系。方法:根據(jù)病例選擇標準,共納入19例RE患兒。采用EEG-fMRI技術(shù)采集患兒腦功能數(shù)據(jù),排除無發(fā)作間期癇樣放電(IED)的和頭動過大的病例,獲得12例患兒的fMRI數(shù)據(jù)。采用廣義線性模型(GLM)方法分析IED相關(guān)血氧水平依賴(BOLD)信號改變,計算腦區(qū)激活偏側(cè)系數(shù)及EEG偏側(cè)系數(shù),并分析兩者的相關(guān)性。結(jié)果:左側(cè)及右側(cè)IED為主的組分析顯示BOLD信號激活主要位于同側(cè)外側(cè)裂-中央?yún)^(qū),個體分析顯示10例患兒外側(cè)裂-中央?yún)^(qū)范圍內(nèi)BOLD信號顯著激活。中央后回和中央溝蓋區(qū)、中央前回腦區(qū)激活偏側(cè)系數(shù)與EEG偏側(cè)性顯著相關(guān)(P0.01)。結(jié)論:fMRI上激活腦區(qū)和EEG信號偏側(cè)性具有相關(guān)性,中央后回和中央溝蓋區(qū)最適合作為描述RE偏側(cè)性的目標腦區(qū)。
[Abstract]:Objective: to analyze the relationship between the laterality of the activated area and the hemiplegia of electroencephalogram (EEG) in patients with Rolandic epilepsy by synchronous EEG combined with functional magnetic resonance imaging (EEG-fMRI). Methods: according to the criteria of case selection, 19 children with RE were included. Brain function data were collected by EEG-fMRI technique to exclude the patients without interictal epileptiform discharges (IEDs) and large head movement. FMRI data were obtained from 12 children. The changes of IED related blood oxygen level dependent Bod signals were analyzed by using generalized linear model (GLM), and the activation hemivariate coefficients and the EEG hemicoefficients were calculated. Results: the BOLD signal activation was mainly located in the ipsilateral lateral fissure and central region in the left and right IED groups. Individual analysis showed that the BOLD signal was activated significantly in the lateral fissure and central area in 10 cases, the posterior central gyrus and the central sulcus cover area were significantly activated. There is a significant correlation between the activation hemiplegia coefficient of precentral gyrus and the hemiplegia of EEG. Conclusion there is a correlation between the activated brain area on EEG and the laterality of EEG signal, and the posterior central gyrus and the central sulcus tectum are the most suitable target areas for describing RE laterality.
【作者單位】： 徐州醫(yī)學(xué)院;徐州醫(yī)學(xué)院附屬南京軍區(qū)南京總醫(yī)院影像科;徐州醫(yī)學(xué)院附屬南京軍區(qū)南京總醫(yī)院神經(jīng)內(nèi)科;南京兒童醫(yī)院神經(jīng)內(nèi)科;
【基金】：國家自然科學(xué)基金(81271553;81422022)
【分類號】：R445.2;R742.1

【參考文獻】

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本文編號：1589177