【摘要】：目的探討中性粒細(xì)胞與淋巴細(xì)胞比值(NLR)評(píng)估谷丙轉(zhuǎn)氨酶(ALT)2倍正常值上限的慢性乙型肝炎病毒(HBV)感染患者肝臟炎癥活動(dòng)度的臨床價(jià)值。方法選取117例ALT2倍正常值上限的慢性HBV感染患者進(jìn)行肝臟穿刺病理學(xué)檢查,同時(shí)采用全自動(dòng)生化分析儀和全血細(xì)胞分析儀分析患者外周血中ALT、谷草轉(zhuǎn)氨酶(AST)、白蛋白(ALB)、中性粒細(xì)胞計(jì)數(shù)和淋巴細(xì)胞計(jì)數(shù)等指標(biāo)。采用Pearson相關(guān)系數(shù)分析患者NLR比值與肝臟炎癥指標(biāo)的相關(guān)性。以肝臟穿刺病理學(xué)結(jié)果為"金標(biāo)準(zhǔn)",通過(guò)受試者工作特征曲線(ROC)評(píng)估NLR比值在鑒別肝臟炎癥活動(dòng)度≥2的慢性HBV感染患者的敏感度和特異度。結(jié)果 117例ALT2倍正常值上限的慢性HBV感染患者中,肝臟炎癥活動(dòng)度分級(jí)為G0、G1、G2及G3患者所占比例分別為4.27%、45.28%、44.44%及5.12%。ALT2倍正常值上限的慢性HBV感染患者NLR比值隨著肝臟炎癥活動(dòng)度分級(jí)升高而逐漸增高,并分別與ALT和AST呈正相關(guān)性(r=0.307、0.349,P=0.001)。ROC曲線分析結(jié)果顯示,NLR比值鑒別肝臟炎癥活動(dòng)度分級(jí)≥2的慢性HBV感染患者時(shí),ROC曲線下面積為0.84,顯著高于ALT和AST曲線下面積0.65和0.63,差異有統(tǒng)計(jì)學(xué)意義(P=0.001)。結(jié)論部分ALT2倍正常值上限的慢性HBV感染患者肝臟存在較嚴(yán)重的炎癥病變,NLR具有評(píng)估該部分患者肝臟炎癥活動(dòng)度的臨床應(yīng)用價(jià)值。
[Abstract]:Objective to investigate the clinical value of neutrophil / lymphocyte ratio (NLR) in evaluating liver inflammatory activity in patients with chronic hepatitis B virus (HBV) infection with glutamic-pyruvic transaminase (ALT). Methods liver puncture pathology was performed in 117 patients with chronic HBV infection with the upper limit of ALT2 times normal value. ALT, glutamic oxaloacetic transaminase (AST), in peripheral blood was analyzed by automatic biochemical analyzer and whole blood cell analyzer. Albumin (ALB), neutrophil count and lymphocytes count. The correlation between NLR ratio and liver inflammation index was analyzed by Pearson correlation coefficient. According to the results of liver puncture pathology as the "gold standard", the sensitivity and specificity of NLR ratio in distinguishing patients with chronic HBV infection with liver inflammatory activity 鈮，

本文編號(hào)：2491108