【摘要】：在病毒性肝炎疾病進展的過程之中,淋巴細胞向受病毒感染的肝組織遷移及侵潤,對抗病毒免疫應(yīng)答和炎癥反應(yīng)的發(fā)生起著至關(guān)重要的作用,但對其機理的研究尚未取得令人滿意的答案。近幾年來,CXC趨化因子配體(CXC chemokine ligand,CXCL)10是目前研究較多的一個細胞因子,其受體是CXCR3,兩者之間的相互作用已成為病毒性肝炎的發(fā)生及發(fā)展機制的重要突破點。本文就CXCL10在病毒性肝炎中的意義及對抗病毒療效評估的相關(guān)研究進展作一綜述。CXCL10,又名干擾素γ誘導蛋白10,屬于CXC亞家族中的ELR—趨化因子,CXCL10主要與趨化因子受體CXCR3結(jié)合而發(fā)揮作用,其主要作用包括促進細胞趨化、誘導細胞凋亡、調(diào)節(jié)細胞生長和增殖及調(diào)節(jié)血管生成等;多項研究顯示,慢性HBV、HCV感染者血清及肝組織CXCL10表達水平增高,且隨著肝臟炎癥及纖維化程度的加重,CXCL10水平也隨之增加,提示了CXCL10在肝臟病理損傷過程中可能發(fā)揮了重要的作用;在應(yīng)用抗HBV、HCV藥物治療后,血清CXCL10水平逐漸下降,提示CXCL10在病毒清除過程中可能發(fā)揮了重要作用,并發(fā)現(xiàn)血清CXCL10基線水平及治療過程中CXCL10的下降幅度可能有效預(yù)測抗病毒療效。但CXCL10參與病毒性肝炎病理過程的機制及在抗病毒治療過程中的作用機制尚不清楚,仍需要進一步研究。
[Abstract]:In the progress of viral hepatitis disease, lymphocyte migration and infiltration into the infected liver tissue, anti-viral immune response and inflammatory response plays a vital role. However, the study of its mechanism has not yet obtained a satisfactory answer. In recent years, CXC chemokine ligand (CXC chemokine ligand,CXCL) 10 is one of the most widely studied cytokines. Its receptor is an important breakthrough point of the mechanism of occurrence and development of viral hepatitis. This article reviews the significance of CXCL10 in viral hepatitis and the related research progress in the evaluation of antiviral efficacy. CXCL10, also known as interferon 緯 inducible protein 10, belongs to the ELR- chemokine in the CXC subfamily. CXCL10 mainly binds to chemokine receptor CXCR3. Its main functions include promoting cell chemotaxis, inducing apoptosis, regulating cell growth and proliferation, and regulating angiogenesis. A number of studies have shown that the expression of CXCL10 in serum and liver tissues of chronic HBV,HCV infected patients increased, and with the severity of liver inflammation and fibrosis, the level of CXCL10 also increased. The results suggest that CXCL10 may play an important role in the process of liver pathological injury. The level of serum CXCL10 decreased gradually after treatment with antiviral HBV,HCV drugs, suggesting that CXCL10 may play an important role in the process of virus clearance. It was found that the baseline level of serum CXCL10 and the decrease of CXCL10 in the course of treatment might be effective in predicting the antiviral effect. However, the mechanism of CXCL10 involved in the pathological process of viral hepatitis and its role in antiviral therapy are still unclear, and need to be further studied.
【學位授予單位】：河北醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R512.6

【參考文獻】

相關(guān)期刊論文 前10條

1 郝潔;田小軍;宋新文;申保生;段樹鵬;;聚乙二醇干擾素對慢性丙肝患者血清炎癥細胞因子及抗體水平的影響[J];山東醫(yī)藥;2016年40期

2 張健;吳友偉;呂颯美;史麗萍;周健;;血清IP-10 MIG IL-8及RANTES水平變化與肝癌進展關(guān)系分析[J];西部醫(yī)學;2015年09期

3 蘇然;熊亞莉;劉勇;黃睿;王貴陽;嚴曉敏;陳軍浩;吳超;;不同免疫狀態(tài)下慢性HBV感染者外周血調(diào)節(jié)性B細胞及血清IL-10和IP-10的表達特點[J];中華實驗和臨床感染病雜志(電子版);2015年04期

4 李曉陽;張強;易顯富;袁情;唐文娟;;趨化因子CXCL10啟動子區(qū)-201G/A多態(tài)性與慢性乙型肝炎易感相關(guān)性研究[J];海南醫(yī)學;2015年14期

5 王可寧;楊紅園;褚瑞海;劉松;曲孝陽;;血清趨化因子IP-10在慢性HBV感染者中的表達及意義[J];遼寧醫(yī)學院學報;2015年02期

6 Francesca Capone;Eliana Guerriero;Giovanni Colonna;Patrizia Maio;Alessandra Mangia;Giuseppe Castello;Susan Costantini;;Cytokinome profile evaluation in patients with hepatitis C virus infection[J];World Journal of Gastroenterology;2014年28期

7 王亞東;張莉;申川;曹偉;趙亞娟;甄真;趙彩彥;;慢性乙型肝炎病毒感染者不同階段γ干擾素及其誘導蛋白10表達變化[J];中華傳染病雜志;2014年01期

8 李文莉;吳茂盛;黃育波;朱計芬;劉細玲;許瑞榮;;干擾素α-2b對慢性乙型肝炎患者血清干擾素誘導蛋白、活性調(diào)節(jié)蛋白水平的影響[J];中國基層醫(yī)藥;2012年09期

9 楊華;羅亞文;劉華慶;侯文;李佳;;慢性乙型肝炎患者肝組織CXCR3及其配體IP 10表達與肝臟炎癥程度、纖維化的相關(guān)性研究[J];第三軍醫(yī)大學學報;2012年03期

10 李紹民;劉國華;鄧李玲;;替比夫定對慢性乙型肝炎患者外周血IP-10、Fractalkine水平影響及其臨床意義的探討[J];黑龍江醫(yī)藥科學;2012年01期

，

本文編號：2369103