【摘要】：目的通過分析慢性乙型肝炎、乙肝肝硬化、慢性肝衰竭患者外周血T淋巴細(xì)胞亞群百分比變化,探討T細(xì)胞亞群變化與不同臨床類型慢乙肝患者病程之間的關(guān)系。方法采用流式細(xì)胞儀技術(shù),檢測36例慢性乙型肝炎患者、55例乙肝肝硬化患者、20例慢性肝衰竭患者外周血CD3+T、CD4+T、CD8+T淋巴細(xì)胞百分比及CD4+T/CD8+T細(xì)胞百分比比值。結(jié)果(1)CD3+T、CD8+T細(xì)胞百分比在慢性乙型肝炎組、乙肝肝硬化組、慢性肝衰竭組三組間進(jìn)行比較,差異具有統(tǒng)計學(xué)意義(P0.05)。且CD3+T、CD8+T細(xì)胞百分比在三組間的差異存在一定規(guī)律,隨著疾病進(jìn)展,CD3+T、CD8+T細(xì)胞百分比呈逐漸下降趨勢,即:慢性乙型肝炎組乙肝肝硬化組慢性肝衰竭組。(2)CD4+T細(xì)胞百分比、CD4+T/CD8+T細(xì)胞百分比比值在慢性乙型肝炎組、乙肝肝硬化組、慢性肝衰竭組三組間進(jìn)行比較,差異無統(tǒng)計學(xué)意義(P0.05)。(3)CD3+T、CD8+T細(xì)胞百分比分別在三組之間行兩兩比較,研究結(jié)果顯示,慢性乙型肝炎組與乙肝肝硬化組比較差異無統(tǒng)計學(xué)意義(P0.05)。慢性肝衰竭組與慢性乙型肝炎組比較,差異有統(tǒng)計學(xué)意義(P0.05)。慢性肝衰竭組與乙肝肝硬化組比較,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論不同臨床類型慢乙肝患者,隨著疾病進(jìn)展,外周血T淋巴細(xì)胞亞群百分比逐漸下降,其中慢性肝衰竭患者T淋巴細(xì)胞下降尤為明顯。監(jiān)測外周血T淋巴細(xì)胞亞群變化,可作為判定病情發(fā)展階段及評估預(yù)后的重要指標(biāo)。
[Abstract]:Objective to analyze the percentage of T lymphocyte subsets in peripheral blood of patients with chronic hepatitis B, liver cirrhosis and chronic liver failure, and to explore the relationship between the changes of T lymphocyte subsets and the course of disease in patients with chronic hepatitis B. Methods flow cytometry was used to detect the percentage of CD3 T 4 T T cell and the percentage of CD4 T/CD8 T cells in peripheral blood of 36 patients with chronic hepatitis B, 55 patients with liver cirrhosis and 20 patients with chronic liver failure. Results (1) the percentage of CD3 T 8 T cells in chronic hepatitis B group, hepatitis B cirrhosis group and chronic liver failure group were compared, the difference was statistically significant (P0.05). The percentage of CD8 T cells in CD3 Tnn was different among the three groups. With the disease progression, the percentage of CD8 T cells in CD3 Tnr decreased gradually, and the percentage of CD8 T cells decreased gradually with the development of the disease. (2) the percentage of CD4 T cells and the ratio of CD4 T/CD8 T cells in chronic hepatitis B group, hepatitis B cirrhosis group and chronic liver failure group were compared among three groups. There was no significant difference (P0.05). (3) in the percentage of CD3 T 8 T cells between the three groups. The results showed that there was no significant difference between chronic hepatitis B group and hepatitis B cirrhosis group (P0.05). Chronic liver failure group and chronic hepatitis B group, the difference was statistically significant (P0.05). Chronic liver failure group and liver cirrhosis group, the difference was statistically significant (P0.05). Conclusion the percentage of T lymphocyte subsets in peripheral blood of patients with different clinical types of chronic hepatitis B decreased with the progression of the disease, especially in patients with chronic liver failure. Monitoring the changes of T lymphocyte subsets in peripheral blood can be used as an important index to judge the stage of disease development and to evaluate the prognosis.
【學(xué)位授予單位】：寧夏醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R512.62

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