發(fā)布時(shí)間：2018-10-25 09:44

【摘要】：目的探討HBe Ag陽(yáng)性的慢性乙型肝炎患者HBs Ag定量與HBe Ag、HBV DNA、HBV基因型的關(guān)系。方法收集2014年1~12月于煙臺(tái)市傳染病醫(yī)院首診的154例HBe Ag陽(yáng)性慢性乙型肝炎患者的資料,比較不同基因型患者HBs Ag定量、HBe Ag定量及HBV DNA水平,并采用Sperman相關(guān)系數(shù)評(píng)價(jià)HBs Ag定量與HBe Ag水平和HBVDNA定量的相關(guān)性。結(jié)果154例患者基因型分布為:B型48例,C型104例,非B非C型2例。C基因型HBe Ag陽(yáng)性CHB患者的HBs Ag水平[4.0(2.6,5.5)log10IU/ml]和HBV DNA水平[6.8(4.3,8.5)log10 copies/ml]高于B基因型患者[4.0(2.6,5.0)log10IU/ml,6.5(3.7,7.8)log10copies/ml],且差異有統(tǒng)計(jì)學(xué)意義(均P0.05),HBe Ag水平二者差異無(wú)統(tǒng)計(jì)學(xué)意義。采用sperman相關(guān)分析比較HBs Ag定量、HBe Ag定量及HBV DNA定量的關(guān)聯(lián),結(jié)果HBs Ag水平與HBe Ag水平呈負(fù)相關(guān),相關(guān)系數(shù)r=-0.42,P=0.005;HBs Ag水平與HBV DNA水平呈負(fù)相關(guān),r=-0.43,P=0.03。結(jié)論 HBs Ag定量與HBe Ag、HBV DNA、乙肝基因分型存在一定程度的關(guān)聯(lián),建議同時(shí)檢測(cè)上述指標(biāo)以指導(dǎo)臨床診療。
[Abstract]:Objective to investigate the relationship between HBs Ag quantification and HBe Ag,HBV DNA,HBV genotype in patients with HBe Ag positive chronic hepatitis B. Methods the data of 154 patients with HBe Ag positive chronic hepatitis B who were first diagnosed in Yantai Infectious Disease Hospital from January to December 2014 were collected and the quantitative, HBe Ag and HBV DNA levels of HBs Ag were compared among different genotypes. Sperman correlation coefficient was used to evaluate the correlation between HBs Ag quantification, HBe Ag level and HBVDNA quantification. Results the genotypes of 154 patients were as follows: type B 48, C 104. The levels of HBs Ag [4.0 (2.6 ~ 5.5) log10IU/ml] and HBV DNA [6.8 (4.3 ~ 8.5) log10 copies/ml] in patients with HBe Ag positive CHB were significantly higher than those in patients with genotype B [4.0 (2.6 ~ 5.0) log10IU/ml,6.5 (3.77.8) log10copies/ml], and there was no significant difference between them (P0.05). Sperman correlation analysis was used to compare HBs Ag quantitative, HBe Ag quantitative and HBV DNA quantitative correlation. The results showed that there was a negative correlation between HBs Ag level and HBe Ag level, and a negative correlation between HBs Ag level and HBV DNA level, and a negative correlation between HBs Ag level and HBV DNA level. Conclusion the quantitative analysis of HBs Ag is associated with the genotyping of HBe Ag,HBV DNA, hepatitis B to some extent. It is suggested that the above indexes should be detected simultaneously to guide clinical diagnosis and treatment.
【作者單位】： 山東省濱州醫(yī)學(xué)院;濱州醫(yī)學(xué)院基礎(chǔ)學(xué)院免疫學(xué)教研室;
【分類號(hào)】：R512.62

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本文編號(hào)：2293326