抗病毒治療1年后的療效評價及病毒抑制失敗影響因素分析
發(fā)布時間：2018-10-09 13:37
【摘要】：目的了解抗艾滋病病毒(HIV)治療情況并進(jìn)行療效評價,探索抗病毒治療(ART)病毒抑制失敗的影響因素,提出改進(jìn)ART效果的措施。方法收集成都市疾病預(yù)防控制中心性病艾滋病防治科所提供的成都市HIV感染者/艾滋病(AIDS)病人(簡稱HIV/AIDS病人)抗病毒治療的隨訪資料,對資料進(jìn)行清理分析。結(jié)果共收集1682例HIV/AIDS病人,經(jīng)標(biāo)準(zhǔn)方案治療1年后CD_4~+T淋巴細(xì)胞計(jì)數(shù)從(184.49±103.82)個/μL上升到(313.11±157.41)個/μL,ART前后差異有統(tǒng)計(jì)學(xué)意義(t=-40.778,P0.001)。病毒抑制失敗86例,失敗率為5.1%。擬合多因素Logistic回歸分析發(fā)現(xiàn),年齡[比值比(OR)=2.073,95%可信區(qū)間(CI)=1.012~4.248,P=0.046]、漏服(OR=5.994,95%CI=2.314~15.528,P0.001)及治療方案(OR=2.059,95%CI=1.223~3.467,P=0.007)與病毒抑制失敗的關(guān)系具有統(tǒng)計(jì)學(xué)意義。結(jié)論漏服是影響病毒抑制失敗的主要因素,應(yīng)關(guān)注老年患者的病毒抑制情況,通過提高患者依從性和盡量使用最優(yōu)治療方案來降低病毒抑制失敗率。
[Abstract]:Objective to investigate the effect of anti-HIV (HIV) treatment and evaluate its efficacy, to explore the factors influencing the failure of anti-HIV treatment of (ART) virus, and to put forward the measures to improve the effect of ART. Methods the follow-up data of HIV / (AIDS) patients (HIV/AIDS patients) provided by STD / AIDS Department of Chengdu Center for Disease Control and Prevention were collected and analyzed. Results A total of 1682 patients with HIV/AIDS were collected. The number of CD_4~ T lymphocytes increased from (184.49 鹵103.82) / 渭 L to (313.11 鹵157.41) / 渭 L after 1 year's treatment with standard regimen. 86 cases of virus inhibition failed, the failure rate was 5.1%. Multivariate Logistic regression analysis showed that age [ratio than (OR) 2.073% confidence interval (CI) 1.0124.248P0. 046], OR=5.994,95%CI=2.314~15.528,P0.001 and treatment regimen (OR=2.059,95%CI=1.223~3.467,P=0.007) were significantly correlated with the failure of virus suppression. Conclusion the failure rate of virus suppression should be reduced by increasing compliance of patients and using optimal treatment regimen.
【作者單位】： 四川大學(xué)華西公共衛(wèi)生學(xué)院流行病與衛(wèi)生統(tǒng)計(jì)學(xué)系;成都市疾病預(yù)防控制中心;
【分類號】：R512.91
本文編號：2259532
[Abstract]:Objective to investigate the effect of anti-HIV (HIV) treatment and evaluate its efficacy, to explore the factors influencing the failure of anti-HIV treatment of (ART) virus, and to put forward the measures to improve the effect of ART. Methods the follow-up data of HIV / (AIDS) patients (HIV/AIDS patients) provided by STD / AIDS Department of Chengdu Center for Disease Control and Prevention were collected and analyzed. Results A total of 1682 patients with HIV/AIDS were collected. The number of CD_4~ T lymphocytes increased from (184.49 鹵103.82) / 渭 L to (313.11 鹵157.41) / 渭 L after 1 year's treatment with standard regimen. 86 cases of virus inhibition failed, the failure rate was 5.1%. Multivariate Logistic regression analysis showed that age [ratio than (OR) 2.073% confidence interval (CI) 1.0124.248P0. 046], OR=5.994,95%CI=2.314~15.528,P0.001 and treatment regimen (OR=2.059,95%CI=1.223~3.467,P=0.007) were significantly correlated with the failure of virus suppression. Conclusion the failure rate of virus suppression should be reduced by increasing compliance of patients and using optimal treatment regimen.
【作者單位】： 四川大學(xué)華西公共衛(wèi)生學(xué)院流行病與衛(wèi)生統(tǒng)計(jì)學(xué)系;成都市疾病預(yù)防控制中心;
【分類號】：R512.91
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