【摘要】：目的對比艾滋病病毒(HIV)感染的孕產婦,經孕期與產時不同時期啟動抗反轉錄病毒治療(ART)后艾滋病母嬰阻斷的效果,探討最大程度地減少通過母嬰傳播導致兒童艾滋病感染的方法。方法以30對臨產時才發(fā)現(xiàn)HIV感染并采取緊急方案ART的孕產婦及其嬰兒為觀察組,以90對孕期開始應用ART的HIV感染孕產婦及其嬰兒為對照組,兩組均結合適宜的助產服務和人工喂養(yǎng),嬰兒進行HIV-1核酸和HIV抗體檢測,判斷HIV感染情況并進行對比分析。結果觀察組有1例嬰兒出生3個月死亡,有2例嬰兒2次HIV-1脫氧核糖核酸檢測結果均陽性,診斷嬰兒HIV感染,其余27例滿12~18月齡嬰兒HIV抗體檢測結果陰性,校正后嬰兒HIV感染率為8.17%,對照組90例嬰兒早期診斷和滿12~18月齡HIV抗體檢測結果均為陰性,嬰兒HIV感染率為0,兩組比較差異有統(tǒng)計學意義(χ~2=6.102,P0.05)。結論 HIV感染的孕產婦抗病毒治療可以降低母嬰傳播的風險,孕期開始啟動ART預防艾滋病母嬰傳播的效果明顯優(yōu)于產時緊急ART,結合安全分娩和人工喂養(yǎng)可明顯降低HIV母嬰傳播率。
[Abstract]:Objective to compare the effect of maternal and infant blocking of HIV (HIV) infection in pregnant women during pregnancy and at different stages of labor by initiating anti-retroviral therapy after (ART). To explore ways to minimize HIV infection in children through mother-to-child transmission. Methods Thirty pairs of pregnant women and their infants who had found HIV infection at the time of labor and took emergency ART as observation group and 90 pairs of pregnant women and their infants who began to use ART as control group were used as control group. The infants were tested for HIV-1 nucleic acid and HIV antibody in combination with appropriate midwifery service and artificial feeding. The infection of HIV was judged and compared. Results in the observation group, one infant died at 3 months of birth, two infants were positive for HIV-1 DNA, the other 27 infants were diagnosed with HIV infection. The HIV antibody test results of the other 27 infants over the age of 12 ~ 18 months were negative. The corrected infantile HIV infection rate was 8.17. The early diagnosis of 90 infants in the control group and the detection of HIV antibody at the age of 12 ~ 18 months were all negative, and the infantile HIV infection rate was 0. The difference between the two groups was statistically significant (蠂 ~ (2 / 2) 6.102 (P0.05). Conclusion the antiviral therapy of HIV infection can reduce the risk of mother-to-child transmission. The effect of starting ART during pregnancy to prevent mother-to-child transmission of HIV was significantly better than that of emergency ART, combined with safe delivery and artificial feeding during labor, which could significantly reduce the rate of mother-to-child transmission of HIV.
【作者單位】： 廣西艾滋病臨床治療中心南寧市第四人民醫(yī)院;
【基金】：廣西科學研究與技術開發(fā)計劃項目(桂科攻1355005-1-3)~~
【分類號】：R512.91
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本文編號：2237972