【摘要】：目的對(duì)比艾滋病病毒(HIV)感染的孕產(chǎn)婦,經(jīng)孕期與產(chǎn)時(shí)不同時(shí)期啟動(dòng)抗反轉(zhuǎn)錄病毒治療(ART)后艾滋病母嬰阻斷的效果,探討最大程度地減少通過(guò)母嬰傳播導(dǎo)致兒童艾滋病感染的方法。方法以30對(duì)臨產(chǎn)時(shí)才發(fā)現(xiàn)HIV感染并采取緊急方案ART的孕產(chǎn)婦及其嬰兒為觀察組,以90對(duì)孕期開(kāi)始應(yīng)用ART的HIV感染孕產(chǎn)婦及其嬰兒為對(duì)照組,兩組均結(jié)合適宜的助產(chǎn)服務(wù)和人工喂養(yǎng),嬰兒進(jìn)行HIV-1核酸和HIV抗體檢測(cè),判斷HIV感染情況并進(jìn)行對(duì)比分析。結(jié)果觀察組有1例嬰兒出生3個(gè)月死亡,有2例嬰兒2次HIV-1脫氧核糖核酸檢測(cè)結(jié)果均陽(yáng)性,診斷嬰兒HIV感染,其余27例滿12~18月齡嬰兒HIV抗體檢測(cè)結(jié)果陰性,校正后嬰兒HIV感染率為8.17%,對(duì)照組90例嬰兒早期診斷和滿12~18月齡HIV抗體檢測(cè)結(jié)果均為陰性,嬰兒HIV感染率為0,兩組比較差異有統(tǒng)計(jì)學(xué)意義(χ~2=6.102,P0.05)。結(jié)論 HIV感染的孕產(chǎn)婦抗病毒治療可以降低母嬰傳播的風(fēng)險(xiǎn),孕期開(kāi)始啟動(dòng)ART預(yù)防艾滋病母嬰傳播的效果明顯優(yōu)于產(chǎn)時(shí)緊急ART,結(jié)合安全分娩和人工喂養(yǎng)可明顯降低HIV母嬰傳播率。
[Abstract]:Objective to compare the effect of maternal and infant blocking of HIV (HIV) infection in pregnant women during pregnancy and at different stages of labor by initiating anti-retroviral therapy after (ART). To explore ways to minimize HIV infection in children through mother-to-child transmission. Methods Thirty pairs of pregnant women and their infants who had found HIV infection at the time of labor and took emergency ART as observation group and 90 pairs of pregnant women and their infants who began to use ART as control group were used as control group. The infants were tested for HIV-1 nucleic acid and HIV antibody in combination with appropriate midwifery service and artificial feeding. The infection of HIV was judged and compared. Results in the observation group, one infant died at 3 months of birth, two infants were positive for HIV-1 DNA, the other 27 infants were diagnosed with HIV infection. The HIV antibody test results of the other 27 infants over the age of 12 ~ 18 months were negative. The corrected infantile HIV infection rate was 8.17. The early diagnosis of 90 infants in the control group and the detection of HIV antibody at the age of 12 ~ 18 months were all negative, and the infantile HIV infection rate was 0. The difference between the two groups was statistically significant (蠂 ~ (2 / 2) 6.102 (P0.05). Conclusion the antiviral therapy of HIV infection can reduce the risk of mother-to-child transmission. The effect of starting ART during pregnancy to prevent mother-to-child transmission of HIV was significantly better than that of emergency ART, combined with safe delivery and artificial feeding during labor, which could significantly reduce the rate of mother-to-child transmission of HIV.
【作者單位】： 廣西艾滋病臨床治療中心南寧市第四人民醫(yī)院;
【基金】：廣西科學(xué)研究與技術(shù)開(kāi)發(fā)計(jì)劃項(xiàng)目(桂科攻1355005-1-3)~~
【分類號(hào)】：R512.91
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本文編號(hào)：2237972