【摘要】：目的報道國內(nèi)首例交織帚枝孢霉致透明絲孢霉病。方法患者女,69歲,主因"左前臂結(jié)節(jié)9個月"就診。取結(jié)節(jié)邊緣組織進行病理學(xué)和真菌學(xué)檢查。將組織接種于沙氏培養(yǎng)基、腦心培養(yǎng)基,并對培養(yǎng)物進行形態(tài)學(xué)及rDNA序列測定。結(jié)果組織病理下可見組織細胞肉芽腫及透明真菌孢子和菌絲。組織真菌培養(yǎng)陽性,菌落生長中等速度,為淺灰色絨毛狀菌落。鏡下見無色分枝分隔菌絲,分生孢子梗側(cè)生,分生孢子長圓形,薄壁,1~2個隔。經(jīng)DNA序列分析,與Sarocladium implicatum相似性100%。診斷為透明絲孢霉病,予硝酸舍他康唑乳膏外用及10%碘化鉀溶液口服治療,3個月后患者治愈。結(jié)論根據(jù)其形態(tài)學(xué)特點和DNA序列分析,菌株被鑒定為Sarocladium implicatum。該菌引起的透明絲孢霉病為國內(nèi)首例報道,舍他康唑及碘化鉀聯(lián)合治療本病效果顯著。
[Abstract]:Objective to report the first case of hyaluronema caused by Cladosporium interweavers in China. Methods the patient was 69 years old, mainly due to 9 months of left forearm nodules. Histopathological and mycological examination were performed on the marginal tissues of the nodules. The tissue was inoculated into Salmonella medium, brain heart medium, and the morphology and rDNA sequence of the culture material were determined. Results histocyte granuloma and hyaline fungi spores and hyphae were found in histopathology. The culture of tissue fungi was positive, and the colony grew at a moderate rate, which was light gray villous colony. Colorless branching and separating hyphae, lateral conidia pedicel, oblong conidial, 1 ~ 2 thin-walled septum were observed under microscope. By DNA sequence analysis, the similarity with Sarocladium implicatum was 100%. To diagnose hyaline filamentous mildew, the patients were treated with sertaconazole nitrate cream and 10% potassium iodide orally. The patients were cured after 3 months. Conclusion according to its morphological characteristics and DNA sequence analysis, the strain was identified as Sarocladium implicatum.. The hyaline filamentous mycosis caused by this bacterium is the first reported in China. The effect of the combination of Sertaconazole and potassium iodide on this disease is remarkable.
【作者單位】： 北京大學(xué)第三醫(yī)院皮膚科;
【基金】：國家自然科學(xué)基金(81571967)
【分類號】：R519.8

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1 陳萍;周亞彬;孫婷婷;王興佳;李東明;;交織帚枝孢霉致透明絲孢霉病國內(nèi)首例[J];中國真菌學(xué)雜志;2016年06期

2 汪貴娥;康瑞花;萬力;王麗;林元珠;;1株短帚霉臨床分離株的形態(tài)學(xué)和rDNA序列的鑒定[J];中國真菌學(xué)雜志;2008年03期

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