老年慢性乙型肝炎患者用藥治療后乙肝病毒耐藥基因多位點(diǎn)變異
發(fā)布時(shí)間：2018-08-14 15:29
【摘要】：目的分析拉米夫定(LAM)和恩替卡韋(ECV)聯(lián)合用藥及單獨(dú)用LAM后老年乙肝患者乙肝病毒(HBV)耐藥基因突變位點(diǎn)及與基因型的關(guān)系。方法選擇治療前未檢測(cè)出HBV-YMDD變異的老年乙肝患者100例,隨機(jī)分為兩組,在患者治療后24個(gè)月檢測(cè)基因分型和反轉(zhuǎn)錄酶(RT)區(qū)位點(diǎn)變異。結(jié)果聯(lián)合用藥組中檢出耐藥突變類型分別為rt T184L+L180M+M204V、rt T184L+S202G+L180M+M204V、rt M250L+M204I;單用藥組檢出耐藥基因突變類型分別為rt L180M+M204V、rt L180M+M204I、rt M204I。結(jié)論初期使用LAM聯(lián)合ECV治療老年乙肝患者24個(gè)月后耐藥突變率僅為6%;聯(lián)合用藥在B和C兩種基因型中的耐藥檢出率沒有明顯不同。
[Abstract]:Objective to analyze the relationship between HBV (HBV) resistance gene mutation sites and genotypes in elderly patients with hepatitis B after lamivudine (LAM) and entecavir (ECV) combined with LAM alone. Methods 100 elderly patients with hepatitis B without HBV-YMDD mutation were randomly divided into two groups. Genotyping and reverse transcriptase (RT) site variation were detected 24 months after treatment. Results the mutation types of drug resistance were RT T184L L180M M204V rt T184L S2020G L180M M204VtM250L M204I in combination group and RT L180M M204Vrt M204I204I in single drug group. Conclusion the mutation rate of drug resistance in elderly patients with hepatitis B treated with LAM combined with ECV at the beginning of 24 months was only 60.There was no significant difference in the detection rate of drug resistance between B and C genotypes.
【作者單位】： 河北醫(yī)科大學(xué)第一醫(yī)院檢驗(yàn)科;河北醫(yī)科大學(xué)第四醫(yī)院檢驗(yàn)科;
【基金】：河北省衛(wèi)生廳科研立項(xiàng)(20130565)
【分類號(hào)】：R440;R512.62
本文編號(hào)：2183306
[Abstract]:Objective to analyze the relationship between HBV (HBV) resistance gene mutation sites and genotypes in elderly patients with hepatitis B after lamivudine (LAM) and entecavir (ECV) combined with LAM alone. Methods 100 elderly patients with hepatitis B without HBV-YMDD mutation were randomly divided into two groups. Genotyping and reverse transcriptase (RT) site variation were detected 24 months after treatment. Results the mutation types of drug resistance were RT T184L L180M M204V rt T184L S2020G L180M M204VtM250L M204I in combination group and RT L180M M204Vrt M204I204I in single drug group. Conclusion the mutation rate of drug resistance in elderly patients with hepatitis B treated with LAM combined with ECV at the beginning of 24 months was only 60.There was no significant difference in the detection rate of drug resistance between B and C genotypes.
【作者單位】： 河北醫(yī)科大學(xué)第一醫(yī)院檢驗(yàn)科;河北醫(yī)科大學(xué)第四醫(yī)院檢驗(yàn)科;
【基金】：河北省衛(wèi)生廳科研立項(xiàng)(20130565)
【分類號(hào)】：R440;R512.62
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