【摘要】：目的:探討淋巴瘤合并HBV感染對自體外周血造血干細胞采集及移植后造血重建的影響。方法:收集2006年1月至2014年10月西安交通大學醫(yī)學院第一附屬醫(yī)院40例行自體移植的淋巴瘤患者的臨床資料進行回顧性分析及隨訪。40例患者中8例合并有HBV感染,32例未合并HBV感染,對合并HBV感染者給予預防性應用核苷類似物抗乙肝病毒治療,觀察兩組患者采集的單個核細胞數(shù)及CD34~+細胞數(shù)、造血重建和總生存率及疾病無進展生存率間的差異。結果:40例患者的自體外周血造成血干細胞的采集均達標,兩組患者采集的單個核細胞數(shù)及CD34~+細胞數(shù)無顯著性統(tǒng)計學差異,8例合并HBV感染的患者在移植中均無HBV的再激活。至隨訪結束,合并HBV感染患者1年、3年及5年總生存率和疾病無進展生存率分別為100%、85.7%和57.1%及100%,80%和53.3%,未合并HBV感染患者1年、3年及5年總生存率和疾病無進展生存率分別為100%、88.9%,82.1%及90%,90%和90%。結論:HBV感染對自體外周血造血干細胞的采集和植入可能無影響。預防性應用核苷類似物可有效預防HBV再激活,且對自體外周血造血干細胞采集及植入無影響。
[Abstract]:Objective: to investigate the effect of lymphoma combined with HBV infection on autologous peripheral blood stem cell collection and hematopoietic reconstitution after transplantation. Methods: the clinical data of 40 cases of lymphoma with autologous transplantation in the first affiliated Hospital of Xi'an Jiaotong University Medical College from January 2006 to October 2014 were retrospectively analyzed and 8 of the 40 patients with HBV infection were followed up. 32 cases were not complicated with HBV infection. In order to observe the difference of mononuclear cell count, CD34 ~ cell number, hematopoietic reconstitution and overall survival rate and disease progression survival rate in patients with HBV infection, the prophylactic application of nucleoside analogue against hepatitis B virus (HBV) was performed in the two groups. Results there was no significant difference in the number of mononuclear cells and CD34 ~ cells between the two groups. There was no significant difference in the number of mononuclear cells and CD34 ~ cells between the two groups. There was no reactivation of HBV in 8 patients with HBV infection. Up to the end of the follow-up, The 1-year, 3-year and 5-year overall survival rate and disease progression-free survival rate in patients with HBV infection were 100% and 57.1% and 100% and 53.3%, respectively. The 1-year, 3-year and 5-year overall survival rates and disease-free survival rates in patients with HBV infection were 82.1% and 9090%, respectively. Conclusion the infection of HBV may have no effect on the collection and implantation of autologous peripheral blood stem cells. Prophylactic application of nucleoside analogue can effectively prevent HBV reactivation and has no effect on autologous peripheral blood stem cell collection and implantation.
【作者單位】： 西安交通大學醫(yī)學院第一附屬醫(yī)院血液內科;
【分類號】：R733.1;R512.62

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