【摘要】：目的探討我國手足口病(HFMD)患者的合并癥情況及用藥規(guī)律。方法在中國中醫(yī)科學(xué)院中醫(yī)臨床基礎(chǔ)研究所建立的數(shù)據(jù)倉庫中,選取2006年11月—2011年6月9家三級甲等綜合醫(yī)院醫(yī)院信息系統(tǒng)(HIS)記錄的941例第一診斷為HFMD患者的住院信息。對患者的一般信息、合并癥情況進(jìn)行描述性統(tǒng)計分析,采用頻數(shù)分析法、關(guān)聯(lián)分析探討患者的用藥情況。結(jié)果共625例患者記錄了年齡,其中1~6歲601例(96.2%)。941例患者均記錄了合并癥,發(fā)生率排在前3位的合并癥分別為肺炎(3.9%,37/941)、發(fā)熱(1.4%,13/941)、貧血(1.3%,12/941)。720例患者記錄了用藥情況,使用率排在前3位的西藥分別為維生素(82.8%,596/720)、氯化鉀(33.2%,239/720)、地塞米松(25.6%,184/720),使用率排在前3位的中藥分別為板藍(lán)根(14.4%,104/720)、抗病毒感冒顆粒(10.1%,73/720)、咳喘寧(2.5%,18/720)。關(guān)聯(lián)分析結(jié)果顯示,在1類中藥+1/2/3類西藥的組合方式中,聯(lián)合使用率排在首位的分別為板藍(lán)根+重組人干擾素、板藍(lán)根+匹多莫德+重組人干擾素、板藍(lán)根+對乙酰氨基酚+匹多莫德+重組人干擾素。在常用中、西藥物中,抗病毒感冒顆粒與維生素經(jīng)常聯(lián)合使用,板藍(lán)根與維生素聯(lián)合使用次之。結(jié)論真實(shí)世界中應(yīng)將1~6歲兒童作為HFMD的重點(diǎn)預(yù)防人群,合并癥多由感染引起,以臨床常用中、西藥聯(lián)合使用的治療模式最為常見,同時應(yīng)注意營養(yǎng)支持和預(yù)防感染,清熱解毒類中藥與抗生素聯(lián)合最為常用。
[Abstract]:Objective to investigate the complications of hand, foot and mouth disease (HFMD) in China. Methods from November 2006 to June 2011, 941 patients with HFMD were selected from the data warehouse established by the Institute of Clinical Research of Chinese Academy of traditional Chinese Medicine (CAS). The data were collected from 9 Grade 3A General Hospitals Information system (HIS) from November 2006 to June 2011. The general information and complications of patients were analyzed by descriptive statistics, frequency analysis and association analysis were used to discuss the drug use. Results Age was recorded in 625 patients, including 601 cases (96.2%) of 1 or 6 years of age and 941 cases of complications. The incidence of complications in the top 3 cases were pneumonia (3.937 / 941), fever (1.4% 13 / 941), anemia (1.312 / 941) .720 cases (n = 720). The top three Western medicines were vitamins (82.8n 596 / 720), potassium chloride (33.2 / 239 / 720), dexamethasone (25.6T / 720). The top three Chinese medicines were Radix Isatidis (14.4 / 104 / 720), Anti-virus and Cold granules (10.1 / 73 / 720) and Kechuanning (2.5n 18-720). The results of association analysis showed that in the combination of western medicine of class 1 in 1-2-3, the combined utilization rate was ranked first in the combination of recombinant human interferon in Isatis root, recombinant human interferon in pinidomod of Isatis langenensis, and in the combination mode of combination of western medicine of Chinese medicine in 1-2-3. Isatis root paracetamol acetaminophen pidomod recombinant human interferon. In common use, western medicine, antiviral colds granules and vitamins are often used in combination, Isatis root and vitamin combination next. Conclusion in the real world, children aged 1 to 6 should be regarded as the most important prevention population of HFMD, and the complications are mostly caused by infection. The treatment mode of combined use of western medicine is the most common in clinical use, and attention should be paid to nutrition support and prevention of infection. The combination of antipyretic and antitoxic Chinese medicine and antibiotics is the most commonly used.
【作者單位】： 中國中醫(yī)科學(xué)院針灸研究所;中國中醫(yī)科學(xué)院中醫(yī)臨床基礎(chǔ)醫(yī)學(xué)研究所;
【基金】：中央級公益性科研院所基本科研業(yè)務(wù)費(fèi)專項資金(PY1303、Z00406)
【分類號】：R512.5
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本文編號：2171362