【摘要】：目的探討降脂顆粒劑治療高效抗反轉(zhuǎn)錄病毒治療(HAART)后高脂血癥患者的臨床療效。方法采用實(shí)用性隨機(jī)對(duì)照研究的實(shí)驗(yàn)方法,將58例HAART后高脂血癥的受試者隨機(jī)分為實(shí)驗(yàn)組(HAART+中藥降脂顆粒)、對(duì)照組(HAART+安慰劑),每組29例,同時(shí)測(cè)定治療前、治療后12、24周血脂、肝腎功能等指標(biāo)。兩組均治療6個(gè)月。結(jié)果在實(shí)驗(yàn)組中,降脂顆粒劑在治療24周時(shí)可以顯著降低甘油三酯(TG)的水平,與治療前比較差異有統(tǒng)計(jì)學(xué)意義(t=2.601,P=0.013);在治療12、24周,可提高高密度脂蛋白(HDL-C)的水平,與治療前比較差異有統(tǒng)計(jì)學(xué)意義(12周t=-2.562,P=0.016;24周t=-2.450,P=0.021);而對(duì)照組總膽固醇、TG、HDL-C、低密度脂蛋白治療后均無統(tǒng)計(jì)學(xué)意義。治療12、24周時(shí),實(shí)驗(yàn)組HDL-C的治療效果比對(duì)照組好(12周t=-2.573,P=0.013;24周t=-3.041,P=0.004);治療24周時(shí),實(shí)驗(yàn)組TG的治療效果比對(duì)照組好(t=2.601 P=0.013)。治療24周時(shí),實(shí)驗(yàn)組動(dòng)脈粥樣硬化指數(shù)下降與對(duì)照組相比差異具有統(tǒng)計(jì)學(xué)意義(t=-2.707,P=0.01)。結(jié)論該降脂顆粒劑治療HAART后高脂血癥可以改善脂代謝異常,減少HAART的不良反應(yīng),降低心血管疾病的風(fēng)險(xiǎn)。
[Abstract]:Objective to investigate the clinical efficacy of Jiangzhi granules in treating hyperlipidemia patients after effective antiretrovirus therapy (HAART). Methods Fifty-eight subjects with hyperlipidemia after HAART were randomly divided into experimental group (HAART traditional Chinese medicine Jiangzhi granule) and control group (HAART placebo). Liver and kidney function. Both groups were treated for 6 months. Results in the experimental group, the level of triglyceride (TG) was significantly decreased at 24 weeks after treatment with Jiangzhi granule, and the level of high density lipoprotein (HDL-C) was increased at 1224 weeks after treatment. There was significant difference between the control group and the control group before treatment (12 weeks, t = 2.562, P < 0.016, t = 2.450, P = 0.021), but there was no significant difference between the control group and the control group after the treatment of TGG and HDL-C, low density lipoprotein (LDL) treatment, no significant difference was found between the control group and the control group. The effect of HDL-C in the experimental group was better than that in the control group at the 12th week after treatment (12 weeks, t = 2.573U, P < 0.013), and at 24 weeks, the treatment effect of TG in the experimental group was better than that in the control group (t = 2.601, P = 0.013). The effect of TG in the experimental group was better than that in the control group (t = 2.601 P0. 013). After 24 weeks of treatment, the decrease of atherosclerosis index in the experimental group was significantly lower than that in the control group (t = -2.707, P < 0.01). Conclusion the hyperlipidemia after HAART can improve the abnormal lipid metabolism, reduce the adverse reaction of HAART and reduce the risk of cardiovascular disease.
【作者單位】： 廣州醫(yī)科大學(xué)附屬?gòu)V州市第八人民醫(yī)院;中國(guó)中醫(yī)科學(xué)院艾滋病中心;
【基金】：基金項(xiàng)目:降脂顆粒治療高效抗反轉(zhuǎn)錄病毒治療后脂代謝異常多中心隨機(jī)對(duì)照研究(210507005)~~
【分類號(hào)】：R512.91;R589.2
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本文編號(hào)：2118898