本文選題：慢性乙型肝炎 + 肝臟病理��； 參考：《中華醫(yī)院感染學(xué)雜志》2015年17期

【摘要】：目的分析慢性乙型肝炎(HBV)感染谷丙轉(zhuǎn)氨酶(ALT)持續(xù)正常的患者肝臟病理相關(guān)因素,為慢性乙型肝炎病情判斷提供依據(jù)。方法選取2012年5月-2014年6月接受治療的94例慢性HBV感染ALT持續(xù)正常的患者作為研究對(duì)象,對(duì)患者肝組織病理學(xué)、血清HBV-DNA及HBeAg進(jìn)行檢測(cè),分析患者的肝活檢病理炎癥分級(jí)和纖維化分期、年齡、HBV-DNA載量、血清HBeAg與炎癥和纖維化的關(guān)系。結(jié)果 94例患者均存在炎癥,51例患者存在纖維化,占54.3%,≥40歲患者的炎癥活動(dòng)度較嚴(yán)重,其中炎癥活動(dòng)度≥3,占66.7%,與其他年齡組相比,差異有統(tǒng)計(jì)學(xué)意義(P0.05);≥40歲患者的纖維化程度較高,與其他年齡組比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05);炎癥活動(dòng)度≥3、纖維化分期≥3的患者HBV-DNA載量均高于炎癥活動(dòng)度≤2、纖維化分期≤2的患者,而≥40歲的患者HBV-DNA載量高于其他年齡組,血清HBeAg陰性和陽(yáng)性組炎癥活動(dòng)度≤2、纖維化分期≤2的病例數(shù)與炎癥活動(dòng)度≥3、纖維化分期≥3比較,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論對(duì)于ALT持續(xù)正常的慢性HBV感染者均存在不同程度的肝組織病理學(xué)的改變,其中40歲、病毒數(shù)量及HBeAg陽(yáng)性患者更要注意,必要時(shí)行肝組織活檢。
[Abstract]:Objective to analyze the related factors of liver pathology in patients with chronic hepatitis B (HBV) infection with alanine aminotransferase (alt). Methods 94 patients with chronic HBV infection who received treatment from May 2012 to June 2014 were selected as subjects. The liver histopathology, serum HBV-DNA and HBeAg were detected. The relationship between inflammation and fibrosis, age and HBV-DNA load, serum HBeAg and inflammation and fibrosis were analyzed. Results Fibrosis was found in 51 patients (54.3%) in all 94 patients, and the degree of inflammatory activity was more serious in patients over 40 years old. The inflammatory activity degree was 鈮，

本文編號(hào)：2088592