發(fā)布時(shí)間：2018-06-28 19:01

  本文選題：復(fù)方芪術(shù)湯 + 高效抗反轉(zhuǎn)錄病毒治療��； 參考：《中國艾滋病性病》2015年02期

【摘要】：目的觀察中藥復(fù)方芪術(shù)湯聯(lián)合高效抗反轉(zhuǎn)錄病毒治療(HAART)對艾滋病(AIDS)病人的臨床療效及安全性。方法收集符合抗病毒標(biāo)準(zhǔn)的AIDS病人共74例,將其分為三組:單用HAART組30例,唐草片聯(lián)合HAART組22例,復(fù)方芪術(shù)湯聯(lián)合HAART組22例。每組均治療6個月,觀察3個月及6個月時(shí)CD+4T淋巴細(xì)胞(簡稱CD4細(xì)胞)計(jì)數(shù)、中醫(yī)證候療效及治療過程中有無不良反應(yīng)。結(jié)果唐草片聯(lián)合HAART組治療6個月后,對比HAART組CD4細(xì)胞差異有統(tǒng)計(jì)學(xué)意義(P0.05);復(fù)方芪術(shù)湯聯(lián)合HAART治療6個月后,對比HAART組CD4細(xì)胞差異有統(tǒng)計(jì)學(xué)意義(P0.05);復(fù)方芪術(shù)湯與唐草片兩組之間差異無統(tǒng)計(jì)學(xué)意義(P0.05)。唐草片組、復(fù)方芪術(shù)湯組治療3個月、6個月后,對比單用HAART組,中醫(yī)癥狀體征積分差異均有統(tǒng)計(jì)學(xué)意義(P0.05或P0.01)。其中,唐草片組、復(fù)方芪術(shù)湯組組間差異無統(tǒng)計(jì)學(xué)意義。唐草片組、復(fù)方芪術(shù)湯組治療后3個月和6個月,對比單用HAART組,中醫(yī)證候療效差異均有統(tǒng)計(jì)學(xué)意義(P0.01);兩組之間差異無統(tǒng)計(jì)學(xué)意義。三組病人治療中血常規(guī)、肝功能差異均無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論復(fù)方芪術(shù)湯聯(lián)合HAART治療AIDS病人,對改善中醫(yī)證候療效、提高CD4細(xì)胞計(jì)數(shù)有一定作用,與唐草片聯(lián)合HAART療效相當(dāng)。相比于單用HAART治療方案,復(fù)方芪術(shù)湯聯(lián)合HAART無明顯不良反應(yīng),安全可靠。
[Abstract]:Objective to observe the clinical efficacy and safety of compound Qizu decoction (QZD) combined with highly effective antiretrovirus therapy (HAART) in AIDS patients. Methods 74 AIDS patients who met the antiviral standard were divided into three groups: HAART group (n = 30), Tangcao tablet (n = 22) combined with HAART group (n = 22) and compound Qizhutang (n = 22) combined with HAART group (n = 22). Each group was treated for 6 months. The number of CD4T lymphocytes (CD4 cells) was observed at 3 and 6 months, the curative effect of TCM syndromes and the adverse reactions in the course of treatment were observed. Results after 6 months of treatment, there was a significant difference in CD4 cells between HAART group and Tangcao tablet combined with HAART group (P0.05). Compared with HAART group CD4 cell difference was statistically significant (P0.05); compound Qizhutang and Tangcao tablets had no statistical significance between the two groups (P0.05). Tangcao tablet group, compound Qizu decoction group for 3 months, 6 months later, compared with HAART group, TCM symptoms and signs score differences were statistically significant (P0.05 or P0.01). Among them, Tangcao tablet group and compound Qizu decoction group had no statistical significance. Tangcao tablet group, compound Qizu decoction group 3 months and 6 months after treatment, compared with HAART group, TCM syndromes were significantly different (P0.01), there was no significant difference between the two groups. Three groups of patients in the treatment of blood routine, liver function differences were not statistically significant (P0.05). Conclusion compound Qizhutang combined with HAART has a certain effect on improving TCM syndromes and CD4 cell count, which is similar to Tangcao tablet combined with HAART. Compared with HAART alone, compound Qizu decoction combined with HAART has no obvious adverse reactions and is safe and reliable.
【作者單位】： 復(fù)旦大學(xué)附屬上海市公共衛(wèi)生臨床中心中醫(yī)科;
【基金】：上海申康醫(yī)院發(fā)展中心中醫(yī)藥驗(yàn)方項(xiàng)目(SHDC2012411)~~
【分類號】：R512.91

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本文編號：2079023