本文選題：支原體肺炎 + 醒腦靜注射液��； 參考：《中國老年學(xué)雜志》2017年13期

【摘要】：目的探究醒腦注射液對老年支原體肺炎患者血清腫瘤壞死因子(TNF)-α、C反應(yīng)蛋白(CRP)及免疫功能的影響。方法老年支原體肺炎患者86例依據(jù)抽簽法隨機(jī)分為治療組及對照組各43例。對照組給予常規(guī)抗感染及對癥支持治療方案;治療組在常規(guī)治療的基礎(chǔ)上給予低劑量醒腦靜注射液靜脈滴注。觀察比較兩組治療前、治療48、72 h后血清TNF-α、CRP、白細(xì)胞介素(IL)-6及呼吸音改變情況、高熱、胸悶、氣促、胸腔積液、肺不張情況、高熱持續(xù)時間,咳嗽持續(xù)時間、痰中帶血時間、住院時間、治愈后復(fù)發(fā)率及不良反應(yīng)情況。結(jié)果治療前兩組血清TNF-α、CRP、IL-6、呼吸音異常例數(shù)、高熱例數(shù)、胸悶例數(shù)、氣促例數(shù)、胸腔積液例數(shù)及肺不張例數(shù)比較差異無統(tǒng)計學(xué)意義(P0.05);治療48 h后治療組TNF-α、CRP、IL-6、呼吸音異常例數(shù)、高熱例數(shù)、胸悶例數(shù)及氣促例數(shù)明顯低于對照組(P0.05);治療72 h后治療組血清TNF-α、CRP、IL-6呼吸音改變情況、高熱例數(shù)、胸悶例數(shù)、氣促例數(shù)、胸腔積液例數(shù)及肺不張例數(shù)明顯低于對照組(P0.05);治療組高熱持續(xù)時間、咳嗽持續(xù)時間、痰中帶血時間、住院時間及治愈后復(fù)發(fā)率明顯低于對照組(P0.05);治療過程中治療組出現(xiàn)皮疹、惡心及皮膚瘙癢例數(shù)與對照組,比較差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論應(yīng)用醒腦靜注射液可明顯改善老年支原體肺炎患者治療效果,促進(jìn)病情恢復(fù),降低癥狀的持續(xù)時間并可提高患者免疫力、降低治療后復(fù)發(fā)率,同時無明顯不良反應(yīng)。
[Abstract]:Objective to investigate the effect of Xingnao injection on serum tumor necrosis factor TNF- 偽 -C reactive protein (CRP) and immune function in elderly patients with mycoplasma pneumonia. Methods 86 elderly patients with mycoplasma pneumonia were randomly divided into treatment group (n = 43) and control group (n = 43). The control group was given routine anti-infection and symptomatic support therapy, and the treatment group was given low dose Xingnaojing injection intravenous drip on the basis of routine treatment. The changes of serum TNF- 偽 CRP, interleukin-6 and respiratory sound, high fever, chest tightness, shortness of breath, pleural effusion, atelectasis, duration of high fever, duration of cough, time of blood in sputum were observed and compared between the two groups. Duration of hospitalization, recurrence rate and adverse reactions after cure. Results there was no significant difference in serum TNF- 偽 CRP IL-6, abnormal respiratory tone, hyperpyrexia, chest tightness, shortness of breath, pleural effusion and atelectasis between the two groups before treatment. The number of cases of high fever, chest tightness and shortness of breath were significantly lower than those of control group (P 0.05), and the respiratory sounds of TNF- 偽 CRPIL-6, high fever, chest tightness, shortness of breath were changed in the treatment group 72 hours after treatment. The number of cases of pleural effusion and atelectasis was significantly lower than that of the control group (P 0.05), the duration of high fever, cough, blood in sputum, the time of hospitalization and the recurrence rate after cure in the treatment group were significantly lower than those in the control group (P 0.05). There was no significant difference in the number of cases of nausea and pruritus between the control group and the control group (P 0.05). Conclusion Xingnaojing injection can obviously improve the treatment effect of senile mycoplasma pneumonia patients, promote the recovery of the disease, reduce the duration of symptoms, improve the immunity of the patients, reduce the recurrence rate after treatment, and there is no obvious adverse reaction at the same time.
【作者單位】： 衢州市人民醫(yī)院呼吸科;
【基金】：浙江省公益技術(shù)研究社會發(fā)展項目(2016C33238)
【分類號】：R563.1

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