本文選題：微小RNA + 感染性疾病��； 參考：《中國感染與化療雜志》2015年04期

【摘要】：正哺乳動(dòng)物細(xì)胞內(nèi)非編碼RNA主要有短小干擾RNA(short interfering RNA,siRNA)、微小RNA(microRNA,miRNA)、核仁內(nèi)小分子RNA(small nucleolar RNAs,snoRNA)等[1]。miRNA基因構(gòu)成約3%人類基因組,而人類miRNA總基因數(shù)目有數(shù)千,據(jù)估計(jì),單個(gè)的miRNA可調(diào)控?cái)?shù)百到上千目標(biāo)基因,因此,人類基因約30%~92%可能是由miRNA調(diào)控[2]。1993年,Lee等[3]首先在秀麗隱桿線蟲(Caenorhabditis elegans)體內(nèi)發(fā)現(xiàn)了長度為22 nt的非編碼小RNA——lin-4,同時(shí)發(fā)現(xiàn)lin-4 RNA在lin-14基因的3′UTR(非翻譯區(qū))內(nèi)存在著互補(bǔ)位點(diǎn)。進(jìn)一步研究表明,lin-4 RNA通過與lin-14基因的
[Abstract]:In normal mammalian cells, non-coding RNA mainly consists of short interfering RNA(short interfering siRNAs, small RNAs, RNA(small nucleolar RNAsSsnoRNAs, etc. [1] .miRNAs constitute about 3% of the human genome, while the total number of human miRNA genes is estimated to be several thousand. A single miRNA regulates hundreds to thousands of target genes, so, About 30.2% of human genes may be regulated by miRNA [2]. In 1993, Lee et al. (3) first discovered a small non-coding RNA-lin-4 with a length of 22 NT in Caenorhabditis eleans, and found that lin-4 RNA has complementary sites in 3 UTRs (untranslated region) of lin-14 gene. Further studies have shown that RNA of lin-4 is related to the expression of lin-14 gene.
【作者單位】： 首都醫(yī)科大學(xué)附屬北京兒童醫(yī)院感染科;
【分類號】：R51

【參考文獻(xiàn)】

相關(guān)期刊論文 前6條

1 馬永潔;周U，

本文編號：1975411