本文選題：沙門菌屬 + 侵襲性沙門菌屬感染　； 參考：《首都醫(yī)科大學(xué)學(xué)報(bào)》2017年05期

【摘要】：目的分析總結(jié)侵襲性沙門菌屬感染病例的臨床特點(diǎn)及沙門菌屬的抗生素藥物敏感性,為臨床診治提供依據(jù)。方法回顧性分析首都醫(yī)科大學(xué)附屬北京朝陽醫(yī)院2010年3月至2016年10月住院的23例成人侵襲性沙門菌感染病例的臨床表現(xiàn)、實(shí)驗(yàn)室檢查、治療預(yù)后及抗生素敏感性。結(jié)果 23例病人中位年齡62(19,83)歲,男女比例為17∶6,合并基礎(chǔ)疾病/情況的有18例(78.26%)。12例形成腸外局部感染病人的中位年齡為67.5歲,其中91.67%合并基礎(chǔ)病,4例為感染性動(dòng)脈瘤。臨床表現(xiàn):高熱(T≥39℃)者20例(86.96%),寒戰(zhàn)者21例(91.3%),腹瀉7例(30.43%),全血白細(xì)胞中位數(shù)9.22(2.53,26.33)×109/L,白細(xì)胞10×109/L者13例(56.5%),嗜酸性粒細(xì)胞比例≤0.005者18例(78.26%)。住院病人中19例臨床治愈或好轉(zhuǎn)出院,2例轉(zhuǎn)院治療,死亡2例。環(huán)丙沙星和氨芐西林敏感性較其他6種抗生素低(分別為37.5%和34.78%),且差異具有統(tǒng)計(jì)學(xué)意義,環(huán)丙沙星中介的占到56.25%(9/16)。結(jié)論侵襲性沙門菌感染好發(fā)于中老年及合并基礎(chǔ)疾病者,臨床表現(xiàn)為多種疾病形式,多有寒戰(zhàn)高熱,少有腹瀉,超半數(shù)全血白細(xì)胞不升高且大部分病人嗜酸性粒細(xì)胞減少。動(dòng)脈粥樣硬化病人合并沙門菌血流感染時(shí)要警惕感染性動(dòng)脈瘤的形成。選擇抗生素時(shí)避免氨芐西林及環(huán)丙沙星,可以考慮三代頭孢及左氧氟沙星。
[Abstract]:Objective to analyze the clinical characteristics of invasive Salmonella infection cases and the antibiotic sensitivity of Salmonella so as to provide evidence for clinical diagnosis and treatment. Methods the clinical manifestation, laboratory examination, prognosis and antibiotic sensitivity of 23 adult patients with invasive Salmonella infection in Beijing Chaoyang Hospital affiliated to Capital Medical University from March 2010 to October 2016 were retrospectively analyzed. Results the median age of 23 patients was 62 / 19 / 83), the ratio of male to female was 17: 6. The median age of 18 patients with basic diseases / conditions was 67.5 years old. The median age of 12 patients with local infection was 67.5 years old. Among them, 91.67% of the patients with underlying diseases were infectious aneurysms. The clinical manifestations were as follows: 20 cases with high fever T 鈮，

本文編號：1910511