發(fā)布時(shí)間：2018-05-19 10:11

  本文選題：乙肝相關(guān)性肝癌患者 + 根治性切除術(shù)�。� 參考：《中國(guó)公共衛(wèi)生》2017年11期

【摘要】：目的了解乙肝相關(guān)性肝癌患者行根治性切除術(shù)后預(yù)后的影響因素,為提高肝癌術(shù)后患者的生存質(zhì)量提供參考依據(jù)。方法對(duì)2003年12月—2012年12月在南京軍區(qū)福州總醫(yī)院行根治性肝切除術(shù)的426例乙肝相關(guān)性肝癌患者每2~4個(gè)月進(jìn)行1次電話隨訪,了解其預(yù)后情況;應(yīng)用R 3.1.2統(tǒng)計(jì)軟件采用單因素和多因素Cox回歸分析方法分析乙肝相關(guān)性肝癌患者行根治性切除術(shù)后預(yù)后的影響因素。結(jié)果隨訪的426例乙肝相關(guān)性肝癌患者術(shù)后的平均生存時(shí)間為(42.06±26.7)個(gè)月,其中第1、2、3、4、5年的生存率分別為86.15%、73.71%、66.67%、61.27%、58.92%;多因素Cox回歸分析結(jié)果顯示,腫瘤有血液轉(zhuǎn)移、肝功能Child-Pugh分級(jí)B級(jí)、甲胎蛋白(AFP)含量400 ng/m L、Topo IIα高表達(dá)和飲酒是影響行根治性切除術(shù)后乙肝相關(guān)性肝癌患者預(yù)后的危險(xiǎn)因素;有腫瘤包膜和Edmonson病理分級(jí)I級(jí)是影響行根治性切除術(shù)后乙肝相關(guān)性肝癌患者預(yù)后的保護(hù)因素。結(jié)論腫瘤包膜情況、血液轉(zhuǎn)移情況、Edmonson病理分級(jí)、肝功能Child-Pugh分級(jí)、AFP含量、Topo IIα表達(dá)和飲酒情況是影響行根治性切除術(shù)后乙肝相關(guān)性肝癌患者預(yù)后的主要因素。
[Abstract]:Objective to investigate the prognostic factors of patients with Hepatitis B associated liver cancer after radical resection, and to provide a reference for improving the quality of life of patients with liver cancer. Methods from December 2003 to December 2012, 426 patients with Hepatitis B related liver cancer who underwent radical hepatectomy in Fuzhou General Hospital of Nanjing military region were followed up by telephone every 2 ~ 4 months. Using R3.1.2 statistical software, univariate and multivariate Cox regression analysis was used to analyze the prognostic factors of patients with Hepatitis B associated liver cancer after radical resection. Results the mean survival time was 42.06 鹵26.7months after operation in 426 patients with Hepatitis B associated liver cancer, of which the survival rate of the 1st second trimester was 86.15 and the 5-year survival rate was 86.15. 73.71and 61.27g / 58.92.The multivariate Cox regression analysis showed that the tumor had blood metastasis and liver function Child-Pugh grade B, and the survival rate was 58.92.The results of multivariate Cox regression analysis showed that the tumor had blood metastasis and liver function Child-Pugh grade B, and the survival rate was 86.15%. The high expression of Topo II 偽 and alcohol consumption were the risk factors for the prognosis of Hepatitis B associated liver cancer patients after radical resection. Tumor capsule and Edmonson grade I were the protective factors for the prognosis of patients with Hepatitis B associated liver cancer after radical resection. Conclusion tumor capsule, blood metastasis, liver function Child-Pugh grade and the expression of Topo II 偽 and alcohol consumption are the main factors influencing the prognosis of patients with Hepatitis B associated liver cancer after radical resection.
【作者單位】： 中山大學(xué)公共衛(wèi)生學(xué)院;南京軍區(qū)福州總醫(yī)院肝膽外科;中山大學(xué)中山醫(yī)學(xué)院;深圳市寶安區(qū)疾病預(yù)防控制中心;
【基金】：福建省自然科學(xué)基金重點(diǎn)項(xiàng)目(2014Y0034) 福州總醫(yī)院創(chuàng)新團(tuán)隊(duì)專項(xiàng)資助項(xiàng)目(cxtd05)
【分類號(hào)】：R512.62;R735.7

【相似文獻(xiàn)】

相關(guān)期刊論文 前2條

1 孫建偉;陳豪敏;許汴利;;狂犬病潛伏期及病例暴露后生存與風(fēng)險(xiǎn)變化的Cox回歸分析[J];中國(guó)人獸共患病學(xué)報(bào);2011年08期

2 陳宏義;涂相林;陳家，

本文編號(hào)：1909695