本文選題：慢性乙型病毒性肝炎 + 不同免疫狀態(tài)��； 參考：《桂林醫(yī)學(xué)院》2013年碩士論文

【摘要】：目的：了解廣西桂北地區(qū)慢性HBV感染者不同免疫狀態(tài)外周血T、B細(xì)胞亞群和NK細(xì)胞的數(shù)值、相互關(guān)系及區(qū)別。方法：分析和比較20例免疫耐受狀態(tài)、20例免疫清除狀態(tài)、20例免疫不全狀態(tài)（非活動期）以及20例正常對照組共80例慢性HBV感染者，用流式細(xì)胞儀檢測其外周血淋巴細(xì)胞亞群和NK細(xì)胞，分析其區(qū)別與聯(lián)系。結(jié)果：百分比和絕對數(shù)結(jié)果中，免疫清除組的NK細(xì)胞、CD4+T細(xì)胞及CD4+/CD8+比值較正常對照組減少(P0.05)，，B細(xì)胞、CD8+T細(xì)胞較正常對照組增加(P0.05)。免疫耐受組和免疫不全（非活動組）組的CD4+T細(xì)胞及NK細(xì)胞高于免疫清除組，CD8+T細(xì)胞低于免疫清除組（P0.05）。百分比數(shù)值中，免疫耐受組和免疫不全（非活動期）組的CD4+T細(xì)胞及CD4+/CD8+比值較正常對照組減少(P0.05)，CD8+T細(xì)胞較正常對照組增加(P0.05)，免疫耐受組和免疫不全（非活動組）組CD4+/CD8+高于免疫清除組（P0.05）。絕對值數(shù)值中，免疫耐受組和免疫不全組（非活動組）的CD4+T細(xì)胞較正常對照組減少(P0.05)。結(jié)論：慢性HBV感染者體內(nèi)存在淋巴細(xì)胞亞群失衡和細(xì)胞免疫功能紊亂。外周血淋巴細(xì)胞和NK細(xì)胞的檢測對于了解患者免疫狀態(tài)，評估病情、指導(dǎo)用藥和疫苗開發(fā)有一定的臨床應(yīng)用價值。
[Abstract]:Objective: to understand the correlation and difference between T, B cell subsets and NK cells in peripheral blood of patients with chronic HBV infection in northern Guangxi area. Methods: analysis and comparison of 20 cases of immune tolerance, 20 cases of immune clearance, 20 cases of inactivity (inactive phase) and 20 cases of normal control group, 80 cases of chronic HBV infection, The lymphocyte subsets and NK cells of peripheral blood were detected by flow cytometry. Results: in the results of percentage and absolute number, the ratio of NK cells, CD4+T cells and CD4+/CD8+ in the immune clearance group decreased (P0.05), B cells, CD8+T cells increased (P0.05), and the immune tolerance group and immune system were not immune. The CD4+T cells and NK cells in the whole group were higher than those in the immuno scavenging group, and the CD8+T cells were lower than the immune clearance group (P0.05). In the percentage values, the ratio of CD4+T cells and CD4+/CD8+ in the immune tolerance group and the inactive (inactive) group was less than that in the normal control group (P0.05), and the CD8+T cells were increased (P0.05), the immune tolerance group and the normal control group (P0.05). The CD4+/CD8+ in the inactive group was higher than the immune clearance group (P0.05). In the absolute value, the CD4+T cells in the immune tolerance group and the inactive group (non active group) were less than those of the normal control group (P0.05). Conclusion: the lymphocyte subgroup imbalance and the cellular immune dysfunction in the chronic HBV infected people are in the body and the peripheral blood lymphocyte and NK thin. The detection of cells has certain clinical value for understanding the immune status of patients, evaluating the condition, guiding the use of drugs and vaccine development.
【學(xué)位授予單位】：桂林醫(yī)學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R512.62

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 曹瑋;李太生;;淋巴細(xì)胞亞群與乙型肝炎病毒感染[J];北京醫(yī)學(xué);2012年03期

2 楊麗莎;王釗;覃理靈;何武;周勁剛;吳淋玲;黃亞琴;;HBV感染患者不同免疫狀態(tài)下血清sICAM-1表達(dá)的研究[J];重慶醫(yī)學(xué);2010年23期

3 吳淋玲;楊麗莎;蔣冬香;王繼業(yè);黃亞琴;;廣西桂北地區(qū)慢性HBV感染不同免疫狀態(tài)與HBV基因型關(guān)系研究[J];重慶醫(yī)學(xué);2011年13期

4 王福生;張紀(jì)元;;HBV感染免疫應(yīng)答和免疫治療新進展[J];傳染病信息;2011年04期

5 張政;福軍亮;周春保;張暉;金磊;李慶虹;呂吉云;王福生;;中國乙型肝炎患者外周血淋巴細(xì)胞亞群頻率參考值范圍[J];傳染病信息;2011年04期

6 邵健,董翠英;血清透明質(zhì)酸與單胺氧化酶聯(lián)檢在肝纖維化中的意義[J];放射免疫學(xué)雜志;2005年05期

7 曾小輝;沙衛(wèi)紅;李瑜元;聶玉強;黎慶寧;梁培智;;人外周血NK細(xì)胞亞群的生物學(xué)特性[J];廣東醫(yī)學(xué);2009年09期

8 林英輝;;肝纖維化臨床檢驗血清學(xué)檢測指標(biāo)的研究進展[J];華夏醫(yī)學(xué);2008年04期

9 許為民;;TBA以及肝纖四項在肝病中的檢測意義[J];齊齊哈爾醫(yī)學(xué)院學(xué)報;2011年04期

10 郭術(shù)俊;;流式細(xì)胞術(shù)在免疫學(xué)中的應(yīng)用[J];齊齊哈爾醫(yī)學(xué)院學(xué)報;2012年05期

本文編號：1899525