本文選題：亞臨床型生殖器皰疹 + 病毒脫排��； 參考：《中國皮膚性病學(xué)雜志》2017年05期

【摘要】：目的探討影響亞臨床型生殖器皰疹患者機(jī)體免疫水平的相關(guān)因素,以及予免疫調(diào)節(jié)劑治療后機(jī)體免疫狀態(tài)的改善情況。方法用熒光定量PCR檢測(cè)患者帶毒情況,用流式細(xì)胞儀檢測(cè)患者的免疫功能。比較帶毒陽性組與帶毒陰性組,頻發(fā)組(復(fù)發(fā)≥6次/年)與少發(fā)組(復(fù)發(fā)6次/年)以及使用免疫調(diào)節(jié)劑治療前后患者的外周血淋巴細(xì)胞百分比。結(jié)果帶毒陽性組CD3~+,CD4~+,CD4~+/CD8~+T細(xì)胞均低于帶毒陰性組,差異有統(tǒng)計(jì)學(xué)意義(P0.05),頻發(fā)組CD3~+,CD4~+,CD4~+/CD8~+,NK細(xì)胞均低于少發(fā)組,CD8~+T細(xì)胞高于少發(fā)組,差異有統(tǒng)計(jì)學(xué)意義(P0.05),治療組CD3~+,CD4~+,CD4~+/CD8~+,NK細(xì)胞均低于對(duì)照組,CD8~+T細(xì)胞高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05),治療后CD3~+,CD4~+,CD4~+/CD8~+,NK細(xì)胞均高于治療前,CD8~+T細(xì)胞低于治療前,差異有統(tǒng)計(jì)學(xué)意義(P0.05),在各種分組情況下比較B細(xì)胞數(shù)值變化,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論亞臨床型GH患者存在免疫功能低下的情況,帶毒及頻發(fā)患者的免疫抑制更為嚴(yán)重,而給予聯(lián)合應(yīng)用免疫調(diào)節(jié)劑后免疫低下較前改善。
[Abstract]:Objective to investigate the related factors affecting the immune level of patients with subclinical genital herpes and the improvement of immune status after immunomodulator therapy. Methods fluorescent quantitative PCR and flow cytometry were used to detect the viral status and immune function of the patients. The percentage of peripheral blood lymphocytes was compared between positive group and negative group, frequency group (recurrence 鈮，

本文編號(hào)：1890842